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ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 2  |  Page : 63-69

Ventilatory response to high inspired carbon dioxide concentrations in anesthetized dogs


1 2725 7th Street South, Cranbrook, British Columbia, V1C 4R8, Canada
2 128 Ottawa Avenue South, Saskatoon, Saskatchewan, S7M 3L5, Canada

Correspondence Address:
Jack A Loeppky
2725 7th Street South, Cranbrook, British Columbia, V1C 4R8
Canada
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Source of Support: None, Conflict of Interest: None


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Background : The ventilation ( ) response to inspired CO 2 has been extensively studied, but rarely with concentrations >10%. Aims : These experiments were performed to determine whether would increase correspondingly to higher concentrations and according to conventional chemoreceptor time delays. Materials and Methods : We exposed anesthetized dogs acutely, with and without vagotomy and electrical stimulation of the right vagus, to 20-100% CO 2 -balance O 2 .and to 0 and 10% O 2 -balance N 2 . Results : The time delays decreased and response magnitude increased with increasing concentrations (p<0.01), but at higher concentrations the time delays were shorter than expected, i.e., 0.5 s to double at 100% CO 2 , with the response to 0% O 2 being ~3 s slower. Right vagotomy significantly reduced baseline breathing frequency (fR), increased tidal volume (VT) and increased the time delay by ~3 s. Bilateral vagotomy further reduced baseline fR and , and reduced the response to CO 2 and increased the time delay by ~12 s. Electro-stimulation of the peripheral right vagus while inspiring CO 2 caused a 13 s asystole and further reduced and delayed the response, especially after bilateral vagotomy, shifting the mode from VT to fR. Conclusions : Results indicate that airway or lung receptors responded to the rapid increase in lung H + and that vagal afferents and unimpaired circulation seem necessary for the initial rapid response to high CO 2 concentrations by receptors upstream from the aortic bodies.


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