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CASE REPORT
Year : 2012  |  Volume : 4  |  Issue : 10  |  Page : 507-509

CD45/CD8 myeloid histioid antigen and plasma cell antibody immune response in a case of malignant melanoma


1 Georgia Dermatopathology Associates, Atlanta, USA
2 Dermatology and Skin Surgery Center, Stockbridge, USA
3 Skin Care and Dermatology Associates and Department of Dermatology, Brigham and Women's Hospital, Boston, Massachusetts, USA
4 Department of Surgical Oncology, Emory University Medical Center, Atlanta, Georgia, USA

Correspondence Address:
Ana Maria Abreu-Velez
Georgia Dermatopathology Associates, Atlanta, Georgia
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.102006

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The immune response in metastatic melanoma is not well established and therefore is of particular interest to test for recruitment of immune cells to the tumor. A 46-year-old Caucasian female was evaluated for an asymptomatic right forearm mass. The lesion had been present for at least 4 years and had become painful 4 months ago. Biopsies for hematoxylin and eosin (H and E) staining, as well as immunohistochemical analysis were performed on the primary tumor and on sentinel lymph nodes. The H and E staining was consistent with metastatic melanoma. Positive staining was noted on the tumor cells with S-100, Mart-1/Melan A/CD63, PNL2, HMB45, and tyrosinase. Peritumoral and intratumoral inflammatory cells stained positive for CD8, CD45, PCNA, myeloid histoid antigen, antihuman plasma cell antibody, and focal BRCA1. The staining patterns of CD8/CD45, myeloid histoid antigen and plasma cell antibody on inflammatory cells around the melanoma cells suggest an unusual type of immune response.


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