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REVIEW ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 11  |  Page : 537-547

Newer antibacterials in therapy and clinical trial


1 Consulting Medical Writer and Editor, India
2 Department of Pharmacology, Sri Devaraj Urs Medical College, Tamaka, Kolar, Karnataka, India

Correspondence Address:
Simi S Paknikar
F-502, Nandi Woods, SOS Village Post, Yelenahalli, Begur Hobli, Off Bannerghatta Road, Bangalore- 560 076, Karnataka
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.103312

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In order to deal with the rising problem of antibiotic resistance, newer antibacterials are being discovered and added to existing pool. Since the year 2000, however, only four new classes of antibacterials have been discovered. These include the oxazolidinones, glycolipopeptides, glycolipodepepsipeptide and pleuromutilins. Newer drugs were added to existing classes of antibiotics, such as streptogramins, quinolones, beta-lactam antibiotics, and macrolide-, tetracycline- and trimethoprim-related drugs. Most of the antibacterials are directed against resistant S. aureus infections, with very few against resistant gram-negative infections. The following article reviews the antibacterials approved by the FDA after the year 2000 as well as some of those in clinical trials. Data was obtained through a literature search via Pubmed and google as well as a detailed search of our library database.


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