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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 11  |  Page : 563-568

Bacteriological and resistance profile in isolates from diabetic patients


1 Department of Microbiology, Government Medical College, Haldwani, Uttarakhand, India
2 Department of Medicine, Government Medical College, Haldwani, Uttarakhand, India
3 Department of Surgery, Government Medical College, Haldwani, Uttarakhand, India
4 Department of Biochemistry, Government Medical College, Haldwani, Uttarakhand, India

Correspondence Address:
Monil Singhai
Department of Microbiology, Govt. Medical College, Haldwani - 263 139, Uttarakhand
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.103315

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Background: Diabetes mellitus has become a global epidemic illness and poses a threat for development of resistant bacterial infections. Aim: This study was aimed to know the bacteriological and resistance profile of isolates obtained from diabetic patients. Materials and Methods: The bacterial isolates obtained from various samples of diabetic patients admitted in medicine department in 6-month period were identified and tested for antibiotic susceptibility. The extended spectrum beta-lactamases (ESβL), AmpC, and metallo-beta-lactamases (MβL) enzymes were detected in gram-negative bacilli. Methicillin, macrolide-lincosamide-streptogramin (MLS), and linezolid resistance in Staphylococcus spp. were detected. High-level aminoglycoside resistance (HLAR) in Enterococcus spp. was also tested. Results: In all, 38 of 125 diabetic patients (30.4%) had bacterial infection, 18 patients had wound infections, 18 had urinary tract infections (UTIs), and 2 had respiratory tract infections. Escherichia coli among gram-negative bacteria and Staphylococcus aureus among gram-positive bacteria were the predominant pathogens. 32.5% gram-negative bacilli were AmpC producers, 37.5% were MβL producers, and 40% were ESβL producers. Methicillin and MLS resistance was found in 50% and 33.3% isolates of Staphylococcus spp., respectively. HLAR resistance was alarming in Enterococcus spp. Polymyxin among gram-negative bacteria and vancomycin for gram-positive bacteria were the last resort with highest susceptibility rates to treat infections among diabetic patients. Conclusion: Resistant bacterial infections in diabetic patients are common. The presence of various resistance mechanisms in isolates of our study shows that therapeutic failure can occur if empirical prescription is unsubstantiated.


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