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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 2  |  Page : 90-93

Drug-induced hepatotoxicity in a tertiary care hospital in Rural South India


1 Pharmacology Unit, MAHSA University College, Jalan Elmu Off Jalan University, Kuala Lumpur, Malaysia
2 Department of Pharmacology, Sri Devaraj Urs Medical College, Kolar, Karnataka, India
3 Biochemistry Unit, MAHSA University College, Jalan Elmu Off Jalan University, Kuala Lumpur, Malaysia

Correspondence Address:
Heethal Jaiprakash
Department of Pharmacology, MAHSA University College, Jalan Elmu off Jalan University, Kuala Lumpur
Malaysia
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.93385

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Background: Liver is the main organ for metabolism of drugs and hepatotoxicity is a potential adverse effect for most drugs. Aims: This study was to study the frequency of drug-induced hepatotoxicity and to find the common drugs causing hepatotoxicity. Materials and Methods: The study was conducted at a tertiary care hospital in rural India. It is a study based on case series analysis. All patients with an abnormal liver function report, between July 2006 and July 2007, were included in the study. Results : The study included 411 patients. Among them 141 patients were females and 270 males. The common cause for abnormal liver function was alcoholic liver disease (30.4%) followed by drug-induced hepatotoxicity (15.8%) and malaria (15.3%). Drug-induced hepatotoxicity was seen in 65 patients. It was common in males (55%) compared to females (44%). The mean age of the patients with drug-induced hepatotoxicity was 43±15.9. Antitubercular drugs were the commonly encountered drugs (44%) causing hepatotoxicity followed by lipid lowering agents (41%). The others drugs included antiretroviral drugs (6%),steroids (5%) and chlorpromazine (2%). Conclusion : A thorough history of drug intake must be taken in all patients presenting with abnormal hepatic function.


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