Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 2505
ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 6  |  Page : 257-265

Immune reactivity in psoriatic Munro-Saboureau microabscesses, stratum corneum and blood vessels


1 Georgia Dermatopathology Associates, Atlanta, Georgia, USA
2 Knoxville Dermatopathology Laboratory, Knoxville, Tennessee, USA

Correspondence Address:
Ana Maria Abreu Velez
Georgia Dermatopathology Associates, 1534 North Decatur Rd., NE; Suite 206; Atlanta, Georgia 30307-1000
USA
Login to access the Email id

Source of Support: Georgia Dermatopathology Associates, Atlanta, Georgia, Conflict of Interest: None


DOI: 10.4103/1947-2714.97204

Rights and Permissions

Background: A characteristic feature of early active psoriatic lesions is the intraepidermal penetration of neutrophils, with attendant formation of Munro-Saboureau microabscesses. Previous immunofluorescence studies have shown reactivity of in vivo binding of stratum corneum antibodies (SCAs) within the Munro-Saboreau microabscesses in cases of psoriasis. Aims: In our study, we aimed to investigate any correlation between the SCAs and the Munro-Saboureau microabscesses. Materials and Methods: We investigated 50 archival biopsies of psoriasis with Munro-Saboureau microabscesses, and attempted to confirm antibody colocalization within these microabcesses via immunohistochemistry staining. As controls, we utilized 50 skin biopsies from healthy patients undergoing esthetic plastic surgery procedures. Results: Within the Munro-Saboureau microabscesses, the following markers were statistically significantly positive relative to controls: CD1a, CD8, CD23, cyclooxygenase-2, myeloid histoid antigen, albumin, fibrinogen, kappa, lambda, von Willebrand factor, IgG, IgM, IgD, complement/C3c, C3d, myeloperoxidase, and carcinoembryonic antigen (P < 0.05). Autoreactivity to blood vessels was also detected, with multiple immunoglobulins and complement factors. Conclusions: We document important correlations between the Munro-Saboureau microabscesses, SCAs, and other immunoreactants.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1957    
    Printed115    
    Emailed0    
    PDF Downloaded344    
    Comments [Add]    
    Cited by others 1    

Recommend this journal