|Year : 2012 | Volume
| Issue : 7 | Page : 320-322
Cyanoacrylate glue dressing for hypospadias surgery
Seyed Mohammad Vahid Hosseini, Ahmad Reza Rasekhi, Mohammad Zarenezhad, Arya Hedjazi
Department of Pediatric Surgery, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
|Date of Web Publication||17-Jul-2012|
Children's Hospital, Iranian Legal Medicine Research Center, Bandar Abbas
Source of Support: None, Conflict of Interest: None
Background: Hypospadias repair is a common pediatric operation. Several kinds of dressings are currently available, with their benefits and side effects. Aim: The aim of our study was to introduce a new method of dressing, by pouring several layers of cyanoacrylate (CA) glue as the dressing, in hypospadias surgery. Materials and Methods: Twenty out of the 61 patients with hypospadias, with a mean age of 13.5 months, were enrolled in this study. Forty-one had conventional dressing (pressure wrap dressing), while CA glue was used in 20 patients. CA glue was applied around the penis and its base four times and each time it took one minute to dry. All patients were followed postoperatively for two weeks and six to twelve months, for early and late complications, respectively. Results: One out of 20 developed wound hematoma, one had skin necrosis with infection, and edema was present in all. All these were easily diagnosed and managed rapidly. In the group treated with conventional methods, there were five infections, seven hematomas, all the patients in the group had edema and painful removal of the dressing, and 10 needed repeat dressing. Conclusions: CA glue is impermeable to urine and stool, and prevents edema and hematoma. Used in several layers, it is a good alternative dressing in hypospadias surgery.
Keywords: Cyanoacrylate, Hypospadias, Surgical dressing
|How to cite this article:|
Hosseini SV, Rasekhi AR, Zarenezhad M, Hedjazi A. Cyanoacrylate glue dressing for hypospadias surgery. North Am J Med Sci 2012;4:320-2
|How to cite this URL:|
Hosseini SV, Rasekhi AR, Zarenezhad M, Hedjazi A. Cyanoacrylate glue dressing for hypospadias surgery. North Am J Med Sci [serial online] 2012 [cited 2019 Nov 11];4:320-2. Available from: http://www.najms.org/text.asp?2012/4/7/320/98593
| Introduction|| |
Hypospadias dressing can be kept clean and in place with difficulty, therefore, there are many views on the different methods for postoperative hypospadias dressings.  Generally, a hypospadias dressing should control postoperative edema, prevent hematoma formation that predisposes to infection, as it works as a barrier from the surroundings, especially as home care cleanliness and hygiene may not be ideal. 
Cyanoacrylate (CA)  is an acrylic resin, which rapidly polymerizes in the presence of water, forming long, strong chains, joining the bonded surfaces together. CA is impermeable to water and bacteria, is not easily removable, and peels off by itself. It gives adequate pressure for hemostasis  if it is applied in layers. Previous studies have used a combination of a running polyglycolic acid (PGA) subcutaneous suture, reinforced by CA for surface bonding of the skin, to reduce the rate of fistula formation in urethrocutaneous fistula repair after urethroplasty, and it is used in many surgical practices as a wound sealant, to avoid the use of conventional sutures. , However, in this study, we show how pouring several layers of this glue is more effective in reducing the edema and hemostasis than simple conventional dressing.
| Materials and Methods|| |
From January 2007 to April 2011, 61 patients with B and C class of hypospadias, with a mean age of 13.5 months (range: One to four years), were enrolled by Mouriquand and Mure,  in this study. The entire procedure was described to the parents of the patients and an informed written consent was taken from all of them, according to the Ethical Committee of the University of Medical Sciences.
The patients were randomly divided into two groups. After comparing the age and type of hypospadias, they underwent the Tubularized Incised Plate (TIP) method for repair.  Forty-one patients were treated with conventional dressing for hypospadias, which consisted of a mixture of ointment-covered antibiotic gauze wrap and pressure dressing. In 20 of the 61 patients, CA (Glubran-tiss, Virgilo, Italy) was used for postoperative dressing. A feeding tube that was splinted in the urethra and secured by a suture through the glans, was used at the end of surgery. The penis and surrounding area were cleaned and dried. CA was poured over the glans and it took 60 seconds to set to a rubbery consistency, and this was reapplied four to six times, strengthening the dressing.
It was important to keep the penis straight by using a traction suture. The dressing peeled off in about seven to ten days. All the patients had their stents in a double diaper and received antibiotics and analgesics, and were discharged after 24 hours. They were followed-up for two weeks postoperatively, for early complications such as hematoma, infection, edema, dehiscence, and skin necrosis, and after six to twelve months for late complications, like, stenosis and fistula, unrelated to dressing alone [Figure 1]. 
| Results|| |
The two groups of patients were comparable in terms of age, type of hypospadias (B and C), and use of the TIP method for repair. CA was easier to apply, with no need for removal. The patients and their parents were more comfortable with CA, because it did not get wet or infected and according to its chemical characteristics, had no need for removal.  In conventional dressing, 12 (30%) patients had complications in the form of five infections and seven hematomas, all had painful removal of their dressing, and 10 needed repeat dressing. Only one case of hematoma and one case of skin necrosis with infection were seen in CA (10%). Edema was seen in all the patients, in both groups. All patients in the conventional method needed removal of the dressing, which stuck to the wound, versus no such case in CA. In case of pain, it was Nil is CA group that were significant. However, for other variants a much larger trial was needed for investigation.
The dressing came out spontaneously in CA patients and there was no need for a change, so there was no postoperative pain because of the dressing, therefore, patients felt much less pain in the CA group compared to the patients with the conventional dressing. 
| Discussion|| |
Dressing for hypospadias repair is a controversial issue, however, the most important goals are, easy application, prevention of wound from trauma and contamination, and having pressure on the wound. It is believed that pressure is essential to control postoperative edema and prevent hematoma formation that predisposes to infection. 
Many methods have been described and used in hypospadias surgery, including polyurethrane bioclusive foil, Cavi care, SANAV, glove-finger, Fibrin seal, and Melolin and adhesive membrane.  Prestipino and his colleagues  used CA in four patients with urethrocutanouse fistula, and three had definitive fistula healing. They concluded that fistulae of ≤ 2 mm tended to recover better. In other studies CA was used for simple sharp wounds in the face and extremities (20 patients), inguinal hernia (20 patients), cryptorchidism (20 patients), umbilical hernia (10 patients), hypospadias (17 patients), post-hypospadias fistula repair (8 patients), and cleft lip (5 patients). The results were analyzed in terms of efficacy, cosmetic result, procedure time, material used, and patient comfort, which showed improved results. 
In our study, CA dressing shares many goals with others in restricting edema, hematoma formation, and stabilization, if the wound is treated in several layers and lacks permeability to urine and feces. There is no need for repeated changes or pain on removal, in contrast to the previous methods. The patients are comfortable with the dressing and it keeps wound hygiene in a home care setting, with less complication of 10 versus 30%; however, late complications that were seen to be not directly related to the dressing have been ignored.
| Acknowledgement|| |
The authors wish to thank the staff of the Pediatric Surgery Ward of the Bandar Abbas Children's Hospital.
| References|| |
|1.||van Savage JG, Palanca LG, Slaughenhoupt BL. A prospective randomized trial of dressing versus no dressings for hypospadias repair. J Urol 2000;164:981-3. |
|2.||Gangopadhyay AN, Sharma S. Peha-haft bandage as a new dressing for pediatric hypospadias repair. Indian J Plast Surg 2005;38:162-4. |
|3.||Hosseini SM, Bahador A, Foroutan HR, Sabet B, Geramizadeh B, Zarenezhad M. The application of a new cyanoacrylate glue in pediatric surgery for fistula closure. Iran J Med Sci 2011;36:54-6. |
|4.||Castañón García-Alix M, Sancho Vendrell MA, Parri Ferrandis FJ, San Vicente Vela B, García Aparicio L, Tarrado Castellarnau X, et al. Utility of octyl 2-cyanoacrylate in pediatric surgery. An Pediatr (Barc) 2003;59:548-51. |
|5.||Mouriquand PD, Mure PY. Current concepts in hypospadiology. BJU Int 2004;93 Suppl 3:26-34. |
|6.||Tsur H, Slutzky S, Shafir R. Hypospadias repair with subcutaneous suture and tissue adhesive for surface closure. Plast Reconstr Surg 1979;64:532-5. |
|7.||Skrobisz P, Mikolajczyk A, Fryc D, Bilski P. Use of polyurethane Bioclusive foil from Johnson and Johnson, as a dressing after surgery for hypospadias in children. Wiad Lek 1998;51 Suppl 3:120-3. |
|8.||Prestipino M, Bertozzi M, Nardi N, Appignani A. Outpatient department repair of urethrocutaneous fi stulae using n-butylcyanoacrylate (NBCA): A single-centre experience. BJU Int 2011;108:1514-7. |
|This article has been cited by|
||Experimental study on the chemico-physical interaction between a two-component cyanoacrylate glue and the material of PICCs
| ||Francesca Di Puccio,Daniela Giacomarro,Lorenza Mattei,Mauro Pittiruti,Giancarlo Scoppettuolo |
| ||The Journal of Vascular Access. 2018; 19(1): 58 |
|[Pubmed] | [DOI]|
||2-octyl cyanoacrylate versus reintervention for closure of urethrocutaneous fistulae after urethroplasty for hypospadias: a randomized controlled trial
| ||Gabriela Ambriz-González,Pedro Aguirre-Ramirez,José García-de León,Francisco León-Frutos,Sergio Montero-Cruz,Xóchitl Angélica Trujillo-Trujillo,Clotilde Fuentes-Orozco,Michel Macías-Amezcua,Andrea del Socorro Álvarez-Villaseñor,Ana Cortés-Flores,Mariana Chávez-Tostado,Alejandro González-Ojeda |
| ||BMC Urology. 2014; 14(1): 93 |
|[Pubmed] | [DOI]|
||Endoscopic use of cyanoacrylate glue in the treatment of urethral fistula
| ||Andre Ramos Sorgi Macedo,Silvio Henrique Maia de Almeida,Marco Aurelio de Freitas Rodrigues,Luis Gustavo Toledo,Rafael Agostinho Maioli |
| ||International braz j urol. 2013; 39(4): 602 |
|[Pubmed] | [DOI]|
||Applications of cyanoacrylate glue in pediatric urology
| ||Bertozzi, M. and Appignani, A. |
| ||North American Journal of Medical Sciences. 2012; 4(7): 323-324 |