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ORIGINAL ARTICLE
Year : 2012  |  Volume : 4  |  Issue : 8  |  Page : 331-335

Prevalence and Association of Microalbuminuria in Essential Hypertensive Patients


1 Department of Biochemsitry, Manipal College of Medical Sciences, Pokhara, Nepal
2 Department of Biochemsitry, Institute of Medicine, Kathmandu, Nepal
3 Department of Biochemistry, B. P. Koirala Institute of Health Sciences, Dharan, Nepal
4 Department of Internal Medicine, Nephrology Unit, Institute of Medicine, Kathmandu, Nepal

Correspondence Address:
Bibek Poudel
Department of Biochemsitry, Manipal College of Medical Sciences, Pokhara
Nepal
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.99501

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Background: Microalbuminuria in hypertension has been described as an early sign of kidney damage and a predictor for end stage renal disease and cardiovascular disease. Thus, it is of great importance to study urinary albumin creatinine ratio and progression of kidney disease in hypertensive patients. Aims: The present study was undertaken to find out the prevalence and association of microalbuminuria in newly diagnosed essential hypertension. Materials and Methods: Newly diagnosed essential hypertensive cases (n = 106) and normotensive controls (n = 106) were enrolled. Hypertension was defined according to Joint national committee-VII definitions. Microalbuminuria was measured using an U-Albumin (NycoCard, Norway) and adjusted for urine creatinine. Descriptive statistics and testing of hypothesis were used for the analysis using SPSS 16 software. Results: 51.88% of hypertension cases and 13.2% of normotensive controls had microalbuminuria in total population (odds ratio 7.086, P-value <0.001). 46.67% of cases and 12.08% of controls had microalbuminuria in male population (odds ratio 6.375, P-value <0.001). Similarly, 58.7% of cases and 14.58% of controls had microalbuminuria in female population (odds ratio 8.32, P-value <0.001). Conclusions: By showing strong association between microalbuminuria and hypertension, our findings suggest that microalbuminuria could be a useful marker to assess risk management of cardiovascular disease and renal disease.


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