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ORIGINAL ARTICLE
Year : 2013  |  Volume : 5  |  Issue : 3  |  Page : 207-212

Immunomodulatory activity of aged garlic extract against implanted fibrosarcoma tumor in mice


1 Center for Development and Cooperation of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
2 Department of Pharmacology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran
3 Department of Epidemiology, Pasteur Institute, Tehran, Iran
4 Department of Immunology, Tehran Medical University, Tehran, Iran

Correspondence Address:
Manijeh Yousefi Behzadi
Department of Epidemiology, Pasteur Institute, Tehran
Iran
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Source of Support: Department of Immunology, Tehran Medical University, Tehran, Iran., Conflict of Interest: None


DOI: 10.4103/1947-2714.109191

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Background: Garlic is known as a medicinal herb with broad therapeutic properties ranging from antibacterial to anticancer and even anticoagulant. Aim: Current study was designed to evaluate antitumor effects of aged garlic extract (AGE) on fibrosarcoma tumor in BALB/c mice. Materials and Methods: WEHI-164 fibrosarcoma cells were implanted subcutaneously on day zero into right flank of 40 BALB/c mice aged eight weeks. Mice were randomly categorized in two separate groups: 1 st received AGE (100 mg/kg, intraperitoneally), 2 nd group as control received phosphate buffered saline, (PBS). Treatments were done three times per week. Tumor growth was measured and morbidity was recorded. Subpopulations of CD4+/CD8+ T cells were determined using flow cytometry. WEHI-164 cell specific cytotoxicity of splenocytes and in vitro production of gamma-interferon, (IFN-γ) and Interleukin-4, (IL-4) cytokines were measured. Results: The mice received AGE had significantly longer survival time compared to control mice. The inhibitory effect on tumor growth was seen in AGE treated mice. The CD4+/CD8+ ratio and in vitro IFN-γ production of splenocytes were significantly increased in AGE group. Conclusions: Administration of AGE resulted in improved immune responses against experimentally implanted fibrosarcoma tumors in BALB/c mice. AGE showed significant effects on inhibition of tumor growth and longevity of survival times.


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