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ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 4  |  Page : 168-171

Nicotine alters serum antioxidant profile in male albino Rats


1 Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Osun State; Laboratory for Reproductive and Developmental Programming, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria
2 Laboratory for Reproductive and Developmental Programming, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria

Correspondence Address:
Ibukun Peter Oyeyipo
Department of Physiology, College of Health Sciences, Osun State University, Osun State
Nigeria
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Source of Support: The authors are grateful to the Tertiary Education Trust Fund (TETFUND) Nigeria for funding this research, Conflict of Interest: None


DOI: 10.4103/1947-2714.131240

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Background: Oxidative stress has repeatedly been implicated as the leading cause of several disease conditions. Aim: This study was designed to investigate the effects of nicotine administration on serum antioxidant levels in male albino rats. Materials and Methods: Forty male rats (150-180 g) were divided into five groups and treated orally for 30 days. Group I (control) received 0.2 ml/kg normal saline and Groups II and III received 0.5 and 1.0 mg/kg body weight (BW) of nicotine, respectively for 30 days. The fourth and fifth groups were administered with 0.5 and 1.0 mg/kg BW of nicotine for 30 days, but were left untreated for another 30 days. Serum was assayed for nitric oxide (NO), lipid peroxidation, and antioxidant enzyme. Results: The levels of superoxide dismutase (SOD) and catalase (CAT) were significantly decreased (P < 0.05) in 0.5 and 1.0 mg/kg nicotine treated groups. Glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly decreased (P < 0.05), while NO and malondialdehyde (MDA) were significantly increased (P < 0.05) in 1.0 mg/kg treated group when compared with the control. Conclusion: The present study shows that nicotine administration is associated with decreased serum antioxidant and increase lipid peroxidation ameliorated by nicotine withdrawal in male rat.


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