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REVIEW ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 5  |  Page : 191-198

Atherosclerotic cardiovascular disease risk and evidence-based management of cholesterol


Department of Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, 1 Cooper Plaza, USA

Correspondence Address:
Satyajeet Roy
MD, FACP Department of Medicine, Cooper University Hospital, 1103 North Kings Highway, Suite 203 Cherry Hill, NJ 08034
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.132916

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An elevated level of low-density lipoprotein cholesterol is directly associated with development of atherosclerotic cardiovascular disease, which may present as coronary heart disease, stroke, and peripheral arterial disease. The new cholesterol management guidelines from the American College of Cardiology and the American Heart Association aim to address a comprehensive approach to prevent and reduce the risk of atherosclerotic cardiovascular disease. The new guidelines recommend initiation of heart healthy lifestyle modifications and 3-hydroxy-3-methylglutaryl coenzyme-A reductase inhibitor ("statin") therapy in individuals who are at a high risk for atherosclerotic cardiovascular disease. It is estimated that these guidelines could result in "statin" therapy for one in every three adults in the United States. This article presents a review of the current cholesterol management guidelines, recommendations from relevant randomized controlled trials and meta-analyses obtained from the searches in Medline/PubMed and Cochrane Database of Systematic Reviews, and publications from the Centers for Disease Control and Prevention, the Centers for Medicare and Medicaid Service, and the United States Preventive Services Task Force.


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