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REVIEW ARTICLE
Year : 2015  |  Volume : 7  |  Issue : 6  |  Page : 241-246

Association between periodontitis and Alzheimer's disease


1 Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara, India
2 Department of Prosthodontics, Annasaheb Chudaman Patil Memorial Dental College, Dhule, Maharashtra, India
3 Department of Orthodontics, Maratha Mandal Dental College, Belgaum, Karnataka, India
4 Department of Oral and Maxillofacial Surgery, Annasaheb Chudaman Patil Memorial Dental College, Dhule, Maharashtra, India

Correspondence Address:
Dr Keshava Abbayya
Department of Periodontology, School of Dental Sciences, Krishna Institute of Medical Sciences Deemed University, Karad, Satara-415 110, Maharashtra
India
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.159325

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Alzheimer's disease (AD) is a neurodegenerative disease which significantly increases with age. Its onset can be either early or late. AD is characterized by the salient inflammatory features, microglial activation, and increased levels of proinflammatory cytokines which contribute to the inflammatory status of the central nervous system (CNS). Whereas, periodontitis is a common oral infection associated with the gram negative anaerobic bacteria. Periodontitis can be marked as a "low-grade systemic disease" by release of proinflammatory cytokines into systemic circulation and elevation of C-reactive protein (CRP). Inflammation is known to play a pivotal role in both the disease process serving as a connecting link between periodontitis and AD. The present review throws a light on possible enigmatic link between AD and periodontitis. This review is designed by collecting data from PubMed database using key words like "Alzheimer's disease", "inflammation", "periodontitis", and "proinflammatory cytokines".


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