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ORIGINAL ARTICLE
Year : 2016  |  Volume : 8  |  Issue : 1  |  Page : 40-46

The pathogenesis of rheumatoid arthritis is associated with milk or egg allergy


1 Institue of Allergy and Immunology, School of Medicine, Shen Zhen University, Shenzhen, China
2 Department of Rheumatism, Traditional Chinese Medicine, The Sixth People's Hospital of Shenzhen City, Shenzhen, China
3 Institue of Allergy and Immunology, School of Medicine; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province, College of Optoelectronic Engineering, Shenzhen University, Shenzhen, China

Correspondence Address:
Bo Yang
Rm722, School of Medicine Building, Shenzhen University, Nan Hai Avenue 3688, Shenzhen
China
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.175206

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Background: Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction. Aims: In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant. Materials and Methods: We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model. Results: In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats. Conclusion: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.


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