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ORIGINAL ARTICLE
Year : 2016  |  Volume : 8  |  Issue : 2  |  Page : 88-92

Addition of selenium improves immunomodulative effects of glucan


Department of Pathology, University of Louisville, Louisville, Kentucky, USA

Correspondence Address:
Vaclav Vetvicka
Department of Pathology, University of Louisville, 511 S. Floyd, Louisville - 40292, Kentucky
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.177311

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Background: Selenium (Se) is an established essential nutrient that plays a role in various biological processes including cancer development. Similarly, stimulation of immune reactions by β-glucans is well-documented. Aims: In the current study, we focused on the stimulation of phagocytosis and interleukin (IL)-2 production and on potentiation of anticancer immunity by a combination of glucan with two types of Se. Materials and Methods: Phagocytosis was evaluated using synthetic microspheres; cancer development was measured either using breast cancer cells or using lung cancer cells. Results: Using two different murine models of cancer, we showed that the Se/glucan combination strongly suppressed the growth of cancer, mostly probably via stimulation of immunity. Conclusions: A combination of glucan with Se offers superior stimulation of immunity and inhibition of cancer growth.


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