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CASE REPORT
Year : 2016  |  Volume : 8  |  Issue : 7  |  Page : 312-315

Selective serotonin-norepinephrine reuptake inhibitors-induced Takotsubo cardiomyopathy


1 Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA
2 Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA

Correspondence Address:
Rahul Vasudev
Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey - 07503
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.187153

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Context: Takotsubo translates to "octopus pot" in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC. Case Report: We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far. Conclusion: SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC.


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