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 Table of Contents  
CASE REPORT
Year : 2016  |  Volume : 8  |  Issue : 7  |  Page : 320-322

Acute esophageal necrosis: An update


1 Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, New York City, NY, USA
2 Division of Gastroenterology, Department of Medicine, SUNY Downstate Medical Center, Brooklyn, NY, USA
3 Department of Medicine, Mount Sinai St. Luke's Hospital, Icahn School of Medicine, New York City, NY, USA

Date of Web Publication27-Jul-2016

Correspondence Address:
Faisal Inayat
Department of Medicine, New York-Presbyterian Hospital, Weill Cornell Medical College, 525 East 68th Street, New York City, NY 10065
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.187159

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  Abstract 

Acute esophageal necrosis (AEN) or "black esophagus" is a rare clinical entity with an unclear etiology. It is diagnosed at upper gastrointestinal endoscopy with the presence of strikingly black necrotic esophagus. The treatment is primarily medical, but the prognosis is generally poor due to advanced age and comorbid illnesses in patients who develop AEN. Herein, we discussed the implications of poor glycemic control in regards with AEN and undertook a literature review of this rare diagnosis.

Keywords: Acute esophageal necrosis, awareness, diabetes, hyperglycemic hyperosmolar syndrome


How to cite this article:
Inayat F, Hurairah A, Virk HU. Acute esophageal necrosis: An update. North Am J Med Sci 2016;8:320-2

How to cite this URL:
Inayat F, Hurairah A, Virk HU. Acute esophageal necrosis: An update. North Am J Med Sci [serial online] 2016 [cited 2017 Nov 22];8:320-2. Available from: http://www.najms.org/text.asp?2016/8/7/320/187159


  Introduction Top


Acute esophageal necrosis (AEN) or black esophagus is a rare clinicopathologic entity. The incidence of AEN varies from 0.01% to 0.28%. [1],[2],[3],[4] It is frequently diagnosed by upper endoscopy with the presence of a black, necrotic esophagus. There is no definite etiology identified in patients with AEN, even though a large list of potential associations has been postulated. Upper gastrointestinal hemorrhage is the most common clinical presentation, others being epigastric pain, retrosternal chest discomfort, and dysphagia. However, we report a unique case of AEN in an elderly female who initially presented with hyperosmolar hyperglycemic syndrome (HHS). Only about a hundred cases of AEN have been described in the published literature till this date. [3]


  Case Report Top


A 52-year-old female with diabetes mellitus type I transferred to the SUNY Downstate Medical Center Emergency Department with severe lethargy and obtundation. She presented with arterial hypotension (60/30 mmHg), tachycardia (120 beats/min), and hypoxia (oxygen saturation 73%). Initial laboratory evaluation revealed blood glucose 800 mg/dL, with hemoglobin A1C of 14.3%. Her serum osmolality was 346 mOsmol/L. Urinary and blood ketones were negative. CBC, hepatic, and renal function tests were within normal limits. The clinical picture suggested that the patient had HHS.

24 h after admission, the patient had an episode of hematemesis. Esophagogastroduodenoscopy (EGD) revealed diffuse, circumferential, black-appearing, friable mucosa in the distal third of esophagus [Figure 1]. Biopsies were not taken due to high risk of bleeding and perforation from the severe esophagitis. The patient gradually recovered after conservative treatment with broad-spectrum antibiotics, intravenous proton pump inhibitor, total parenteral nutrition, and oral intake restriction.
Figure 1: Initial upper endoscopy showing necrotic-appearing black esophagus in the lower third of esophagus

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On day 5 of admission, biopsies of the esophagus were obtained with EGD. Histopathology revealed extensive necrosis, absence of viable epithelium, scant stroma, and necrotic debris, consistent with AEN. Her past medical history was only significant for poorly controlled type I diabetes mellitus. She denied tobacco, alcohol, illicit drugs, or nonsteroidal anti-inflammatory drug use. Blood and stool cultures, culture with polymerase chain reaction for cytomegalovirus, hepatitis panel, and HIV testing came out negative. On day 14 of admission, repeat EGD showed resolution of the black mucosa [Figure 2]. Subsequently, she had an uneventful recovery and was discharged from the hospital.
Figure 2: Repeat upper endoscopy 2 weeks after presentation showing resolution of necrotic symptoms in the lower third of esophagus

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  Discussion Top


AEN, black esophagus, or Gurvits syndrome is a striking clinicopathologic entity. It is classically characterized by diffused circumferential black esophagus. [1] The reported incidence of AEN is 0.01-0.28% in selected studies, [2],[3],[4] but true prevalence is likely underestimated due, in part, to transient nature of the insult and propensity of early tissue healing. It preferentially involves elderly male patients. [5] The common clinical presentations and comorbid conditions related to AEN are summarized in [Table 1]. Differential diagnosis includes malignant melanoma, melanocytosis, pseudomelanosis, coal dust deposition, acanthosis nigricans, and caustic ingestion. EGD showing "black esophagus" with a sharp transition to normal mucosa at the gastroesophageal junction is pathognomonic. Histological correlation is recommended, but not required for the diagnosis. [1]
Table 1: Summary of common clinical features and comorbid conditions associated with acute esophageal necrosis

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Previously, several etiologies have been suggested including cardiovascular disease, renal insufficiency, cancer, alcohol intoxication, lye ingestion, candidiasis, herpes simplex virus infection, cytomegalovirus infection, antiphospholipid syndrome, diabetes mellitus, diabetic ketoacidosis (DKA), severe vomiting, acute gastric outlet obstruction, caustic injury from alkaline compounds, bismuth subsalicylate ingestion, medications, Stevens-Johnson syndrome, Henoch-Schonlein purpura, and hypothermia. [1],[2],[3],[4],[5],[6],[7],[8] Recently, a possible link between DKA and AEN has been demonstrated. [5],[9],[10] However, to our research, AEN secondary to HHS has never been reported. This represents the first case of AEN that initially presented with drowsy mentality in the setting of HHS. In such patients, transient nonobstructive gastropathy seen in overt hyperglycemia may have a role in pathogenesis of AEN, [11] adding on to the deleterious effects on the cardiovascular system by diabetes mellitus. [12] In literature, numerous studies have demonstrated that the distal third of esophagus is less vascularized, [13] which makes it susceptible to ischemia caused by low splanchnic blood flow. Therefore, severe hyperglycemia-induced hypovolemia may considerably increase the risk of AEN, especially in patients with diabetes mellitus.

Aggressive treatment of the underlying medical conditions with hemodynamic resuscitation, glycemic control, nil per os restriction, and acid suppression with high-dose intravenous proton pump inhibitors should be immediately instituted in patients with suspected or established AEN. Treatment of underlying HHS was crucial in our case, with complete recovery after supportive care. Major complications of AEN include esophageal stricture and perforation. The incidence of stricture formation was 25% in a recent case series. [1] Esophageal perforation, generally seen in <7% of the cases, [1] is a life-threatening condition that should be suspected in cases with acute decompensation following clinical deterioration. AEN patients who develop esophageal perforation require immediate surgical intervention. Overall mortality in patients with AEN is 32%. However, AEN specific mortality is 6%.

This case and similar AEN cases secondary to poor glycemic control strongly implicate that the clinicians should maintain a high index of suspicion for this esophageal disorder. As the life expectancy is increased leading to increase in old-age (70 years or above) cohort worldwide, this population strata is expected to increase significantly over the next decade. [14] Therefore, if specific knowledge and awareness are not sensitized, and physicians would not be updated on this deadly disease, AEN specific morbidity and mortality may increase owing to the increased number elderly patients with diabetes mellitus. [15],[16]


  Conclusion Top


AEN should be considered as a potential diagnosis of elderly diabetic patients presenting with acute upper gastrointestinal hemorrhage. The development of this disease remains a ''red flag'' for increased overall mortality due to underlying medical conditions. Thereby, AEN prompts a timely diagnosis warranting physicians to have knowledge and awareness on this serious clinical syndrome.

Financial support and sponsorship

Nil.

Conflicts of interest

There are no conflicts of interest.

 
  References Top

1.
Gurvits GE, Cherian K, Shami MN, Korabathina R, El-Nader EM, Rayapudi K, et al. Black esophagus: New insights and multicenter international experience in 2014. Dig Dis Sci 2015;60:444-53.  Back to cited text no. 1
[PUBMED]    
2.
Lacy BE, Toor A, Bensen SP, Rothstein RI, Maheshwari Y. Acute esophageal necrosis: Report of two cases and a review of the literature. Gastrointest Endosc 1999;49:527-32.  Back to cited text no. 2
[PUBMED]    
3.
Day A, Sayegh M. Acute oesophageal necrosis: A case report and review of the literature. Int J Surg 2010;8:6-14.  Back to cited text no. 3
[PUBMED]    
4.
Augusto F, Fernandes V, Cremers MI, Oliveira AP, Lobato C, Alves AL, et al. Acute necrotizing esophagitis: A large retrospective case series. Endoscopy 2004;36:411-5.  Back to cited text no. 4
[PUBMED]    
5.
Worrell SG, Oh DS, Greene CL, DeMeester SR, Hagen JA. Acute esophageal necrosis: A case series and long-term follow-up. Ann Thorac Surg 2014;98:341-2.  Back to cited text no. 5
[PUBMED]    
6.
Iorio N, Bernstein GR, Malik Z, Schey R. Acute esophageal necrosis presenting with Henoch-Schönlein purpura. ACG Case Rep J 2015;3:17-9.  Back to cited text no. 6
[PUBMED]    
7.
Abed J, Mankal P, Judeh H, Kim S. Acute Esophageal Necrosis: A case of black esophagus associated with bismuth subsalicylate ingestion. ACG Case Rep J 2014;1:131-3.  Back to cited text no. 7
[PUBMED]    
8.
Carneiro M, Lescano M, Romanello L, Módena J, Carneiro F, Ramalho L, et al. Acute esophageal necrosis. Dig Endosc 2005;17:89-92.  Back to cited text no. 8
    
9.
Gurvits GE. Black esophagus: Acute esophageal necrosis syndrome. World J Gastroenterol 2010;16:3219-25.  Back to cited text no. 9
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10.
Talebi-Bakhshayesh M, Samiee-Rad F, Zohrenia H, Zargar A. Acute Esophageal necrosis: A case of black esophagus with DKA. Arch Iran Med 2015;18:384-5.  Back to cited text no. 10
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11.
Fraser RJ, Horowitz M, Maddox AF, Harding PE, Chatterton BE, Dent J. Hyperglycaemia slows gastric emptying in type 1 (insulin-dependent) diabetes mellitus. Diabetologia 1990;33:675-80.  Back to cited text no. 11
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12.
Halter JB, Musi N, McFarland Horne F, Crandall JP, Goldberg A, Harkless L, et al. Diabetes and cardiovascular disease in older adults: Current status and future directions. Diabetes 2014;63:2578-89.  Back to cited text no. 12
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13.
Burtally A, Gregoire P. Acute esophageal necrosis and low-flow state. Can J Gastroenterol 2007;21:245-7.  Back to cited text no. 13
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14.
National Centre for Health Statistics. Health, United States. (Accessed January 23, 2016, at: http://www.cdc.gov/nchs/products/pubs/pubd/hus/older.htm#healthstatus).  Back to cited text no. 14
    
15.
Desenclos JC, Bourdiol-Razès M, Rolin B, Garandeau P, Ducos J, Bréchot C, et al. Hepatitis C in a ward for cystic fibrosis and diabetic patients: Possible transmission by spring-loaded finger-stick devices for self-monitoring of capillary blood glucose. Infect Control Hosp Epidemiol 2001;22:701-7.  Back to cited text no. 15
    
16.
Perz JF, Fiore AE. Preventing the transmission of bloodborne viruses during glucose monitoring: Lessons learned from recent outbreaks. J Am Med Dir Assoc 2006;7:65-6.  Back to cited text no. 16
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    Figures

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    Tables

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