North American Journal of Medical Sciences

CASE REPORT
Year
: 2010  |  Volume : 2  |  Issue : 9  |  Page : 433--437

Junctional adhesion molecule overexpression in Kaposi varicelliform eruption skin lesions - as a possible herpes virus entry site


Ana Maria Abreu-Velez1, A Deo Klein2, Michael S Howard1 
1 Georgia Dermatopathology Associates, Atlanta, Georgia, USA
2 Statesboro Dermatology, Statesboro, Georgia, USA

Correspondence Address:
Ana Maria Abreu-Velez
Georgia Dermatopathology Associates, 1534 North Decatur Rd. NE; Suite 206, Atlanta, GA 30307-1000
USA

Context: Herpes simplex virus (HSV) infection of the skin represents a common challenge in dermatology; however, currently the port of viral entry remains obscure. HSV is known to induce an immunoglobulin-binding cell surface receptor in infected cells that utilizes a non-immune mechanism. The replication of HSV in cultured cells is accompanied by the appearance of surface receptors with an affinity for the Fc region of immunoglobulin G. Case Report : We describe a 43 year old African American male who presented with a generalized rash, including intense pruritus and umbilicated vesiculopustules. The patient had been previously diagnosed and treated for psoriasis with methotrexate and prednisone. Methods : Hematoxylin and eosin demonstrated keratinocytes with ballooning degeneration within the epidermis. Direct immunofluorescence (DIF) results resembled the pattern of paraneoplastic pemphigus, with negative indirect immunofluorescence (IIF) results on rat bladder. Immunohistochemistry revealed deposits of the complement membrane attack complex within dermal sweat glands, as well as the presence of herpes simplex virus 1 on the skin. We report a case of Kaposi varicelliform eruption, a cutaneous eruption caused by a virus infecting patients with pre-existing dermatoses. Conclusion: HSV virus infection with over-expression of the junctional adhesion molecule close to herpetic infection sites may preferentially increase viral entry through the skin, possibly triggering a Kaposi varicelliform eruption.


How to cite this article:
Abreu-Velez AM, Klein A D, Howard MS. Junctional adhesion molecule overexpression in Kaposi varicelliform eruption skin lesions - as a possible herpes virus entry site.North Am J Med Sci 2010;2:433-437


How to cite this URL:
Abreu-Velez AM, Klein A D, Howard MS. Junctional adhesion molecule overexpression in Kaposi varicelliform eruption skin lesions - as a possible herpes virus entry site. North Am J Med Sci [serial online] 2010 [cited 2020 Apr 1 ];2:433-437
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2010;volume=2;issue=9;spage=433;epage=437;aulast=Abreu-Velez;type=0