North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 12  |  Page : 565--569

Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA


Harith Jabbar Fahad Al-Mathkhury, Saba Nazeih Abdul-Ghaffar 
 Department of Biology, College of Science, University of Baghdad, Baghdad, Iraq

Correspondence Address:
Harith Jabbar Fahad Al-Mathkhury
Assistant Professor, Department of Biology, College of Science, University of Baghdad, Baghdad
Iraq

Background : Bacterial DNA released upon bacterial autolysis or killed by antibiotics, hence, many inflammatogenic reactions will be established leading to serious tissue damage. Aim : the present work aimed to elucidate the histopathological changes caused by prokaryotic (bacterial) DNA and eukaryotic (candidal) DNA. Materials and Methods : twenty one Staphylococcus aureus and 36 Candida albicans isolates were isolated from UTI patients. Viable cells and DNA of the highest antibiotic sensitive isolates were injected, intraurethraly, in mice. Results were evaluated via histopathological examination. Results: Mildest reactions were obtained from mice challenged with viable C. albicans compared with those challenged with viable S. aureus. Dose-dependent histological changes were observed for both eukaryotic and prokaryotic DNA. However, the eukaryotic C. albicans DNA developed less intense histological changes than S. aureus DNA. Conclusion: microbial DNA has the ability to cause damage in murine renal system. Nevertheless, bacterial DNA caused more intense damage than candidal DNA.


How to cite this article:
Al-Mathkhury HF, Abdul-Ghaffar SN. Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA.North Am J Med Sci 2011;3:565-569


How to cite this URL:
Al-Mathkhury HF, Abdul-Ghaffar SN. Urinary tract infections caused by staphylococcus aureus DNA in comparison to the candida albicans DNA. North Am J Med Sci [serial online] 2011 [cited 2020 Mar 30 ];3:565-569
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=12;spage=565;epage=569;aulast=Al-Mathkhury;type=0