North American Journal of Medical Sciences

REVIEW ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 5  |  Page : 222--226

New insights into procathepsin D in pathological and physiological conditions


Sujata Saraswat-Ohri1, Vaclav Vetvicka2 
1 Kentucky Spinal Cord Injury Centre, Department of Neurological Surgery, Louisville, KY 40202, USA
2 Department of Pathology, University of Louisville, Louisville, KY 40202, USA

Correspondence Address:
Vaclav Vetvicka
Department of Pathology, University of Louisville, 511 S. Floyd St., Louisville, KY 40292
USA

Procathepsin D is a major glycoprotein that is secreted from numerous types of cancer cells including breast, lung and prostrate carcinomas. It affects multiple stages of tumorigenesis that include proliferation, invasion, metastasis and apoptosis. Previous studies showed that the mitogenic effect of procathepsin D on cancer cells was mediated through its propeptide or activation peptide. Recent studies have also implicated the possible use of procathepsin D/activation peptide as a marker of cancer progression. Considering the broad range of functions of procathepsin D, the present review summarizes the three major potentials of procathepsin D-cancer progression, tumor marker and wound healing.


How to cite this article:
Saraswat-Ohri S, Vetvicka V. New insights into procathepsin D in pathological and physiological conditions.North Am J Med Sci 2011;3:222-226


How to cite this URL:
Saraswat-Ohri S, Vetvicka V. New insights into procathepsin D in pathological and physiological conditions. North Am J Med Sci [serial online] 2011 [cited 2020 Mar 30 ];3:222-226
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=5;spage=222;epage=226;aulast=Saraswat-Ohri;type=0