North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 2  |  Page : 86--89

Vitamin E supplementation with Rauwolfia vomitoria root bark extract improves hematological indices


Akpanabiatu Monday Isaiah1, Otitoju Olawale1, Edet Emmanuel Effiong2, Ndem Jessie Idongesit1, Uwah Anthony Fidelis1, Ufot Usenobong Friday3 
1 Department of Biochemistry, College of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
2 Department of Biochemistry, College of Basic Medical Sciences, University of Calabar, Calabar, Nigeria
3 Department of Biological Sciences, Faculty of Natural and Applied Sciences, Akwa Ibom State University, P.M.B. 1167, Uyo, Nigeria

Correspondence Address:
Akpanabiatu Monday Isaiah
Department of Biochemistry, College of Basic Medical Sciences, University of Uyo, P. M. B. 1017, Uyo
Nigeria

Background: Vitamin supplementation in Rauwolfia vomitoria root bark extract administration may interact and impact significantly on hematology of albino Wistar rats. Aim : In this investigation we studied vitamin E supplementation with Rauwolfia vomitoria root bark extract on the hematology of experimental animals. Materials and Methods: Forty two rats weighing 200 - 230 g were randomly selected into six groups of seven animals each. Group 1 animals serve as controls; group 2 received vitamin E (10 IU/kg body weight). Groups 3 and 4 were given the extract (150 and 300 mg/kg body weight) respectively. Groups 5 and 6 were given vitamin E (10 IU/kg body weight), the extract (150 and 300 mg/kg body weight) respectively. The extract and the vitamin were administered daily by oral intubation. Blood samples analyzed for hematological indices. Results : Decrease in white blood cell count (WBC) was observed, indicating improved immunity of animals. Extract at 150 and 300 mg/kg body weight with and without vitamin E affected hemoglobin and packed cell volume. Conclusion : Rauwolfia vomitoria with or without vitamin E improved animal«SQ»s immunity and enhances their hematology. Interaction of vitamin E with the extract affects medicinal therapeutics of this plant.


How to cite this article:
Isaiah AM, Olawale O, Effiong EE, Idongesit NJ, Fidelis UA, Friday UU. Vitamin E supplementation with Rauwolfia vomitoria root bark extract improves hematological indices.North Am J Med Sci 2012;4:86-89


How to cite this URL:
Isaiah AM, Olawale O, Effiong EE, Idongesit NJ, Fidelis UA, Friday UU. Vitamin E supplementation with Rauwolfia vomitoria root bark extract improves hematological indices. North Am J Med Sci [serial online] 2012 [cited 2020 Apr 8 ];4:86-89
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2012;volume=4;issue=2;spage=86;epage=89;aulast=Isaiah;type=0