North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2012  |  Volume : 4  |  Issue : 9  |  Page : 384--388

Aplastic anemia: A common hematological abnormality among peripheral pancytopenia


Haldar Biswajit1, Pal Partha Pratim2, Sarkar Tarun Kumar2, Sharma Shilpi3, Goswami Bidyut Krishna1, Aikat Aditi2 
1 Department of Pathology, North Bengal Medical College, Darjeeling, India
2 Department of Community Medicine, North Bengal Medical College, Darjeeling, India
3 Department of Dermatology, Venereology & Leprology, North Bengal Medical College, Darjeeling, India

Correspondence Address:
Pal Partha Pratim
Department of Community Medicine, North Bengal Medical College, Sushrutanagar, Darjeeling, West Bengal
India

Background: Aplastic anemia is a well-recognized form of marrow failure. The incidence of aplastic anemia is subjected to wide variation. Most cases are acquired and immune-mediated but there are also inherited forms. Aim: The study was conducted to assess the magnitude of the problem, morphological changes and determinants of aplastic anemia in North Bengal. Materials and Methods: A cross-sectional study had been conducted for a period of one year among 5 to 70 years age group. Initially complete blood count followed by bone marrow examination was done for diagnosis. Results: Out of 48 cases, 38 (79.17%) had hypocellular diagnosed as aplastic anemia, 5 (10.42%) each had normocellular and hypercellular bone marrow. Histopathology shows that 30 (78.95%) cases had increased iron stores in bone marrow and 8 (21.05%) cases had decreased iron stores. Subjects less than 20 years of age mostly (31.58%) suffered from non-severe disease in contrast to subjects in higher age groups who had severe or very severe disease, though the trend was not significantly different (χ2 for linear trend 0.171, P > 0.05). Conclusion: The study shows aplastic anemia is a common hematological abnormality among peripheral pancytopenia in North Bengal region where males were affected more than females.


How to cite this article:
Biswajit H, Pratim PP, Kumar ST, Shilpi S, Krishna GB, Aditi A. Aplastic anemia: A common hematological abnormality among peripheral pancytopenia.North Am J Med Sci 2012;4:384-388


How to cite this URL:
Biswajit H, Pratim PP, Kumar ST, Shilpi S, Krishna GB, Aditi A. Aplastic anemia: A common hematological abnormality among peripheral pancytopenia. North Am J Med Sci [serial online] 2012 [cited 2019 Dec 14 ];4:384-388
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2012;volume=4;issue=9;spage=384;epage=388;aulast=Biswajit;type=0