North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 10  |  Page : 611--614

Correlation of severity of coronary artery disease with insulin resistance


Mukund P Srinivasan1, Padmanabh K Kamath2, Poornima A Manjrekar3, B Unnikrishnan4, Aishwarya Ullal5, Mohammed Faheem Kotekar5, Chakrapani Mahabala1 
1 Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
2 Department of Cardiology, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
3 Department of Biochemistry, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
4 Department of Community Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India
5 Jr. Resident, Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka, India

Correspondence Address:
Chakrapani Mahabala
Department of Internal Medicine, Kasturba Medical College, Manipal University, Mangalore, Karnataka
India

Background: Insulin resistance (IR) has known to be associated with coronary artery disease (CAD), but the assessment of severity of the CAD based on IR in type 2 diabetes mellitus has not been established in detail. Aims: The aim of our study was to establish the correlation between IR and the severity of CAD in type 2 diabetes mellitus. Materials and Methods: In a cross-sectional study design, 61 consecutive patients with type 2 diabetes mellitus who underwent coronary angiogram for the evaluation of CAD were recruited. Fasting blood glucose, fasting insulin levels, systolic blood pressure and total cholesterol/high density lipoprotein-cholesterol ratio were determined. Homeostasis model assessment-IR (HOMA-IR) was correlated with severity of CAD, which was measured by modified Gensini Score. Results: There was a significant correlation between log HOMA-IR and severity of CAD (r = 0.303, P = 0.009) in diabetic patients. Correlation of the Gensini Score with other known risk factors was not significant. Conclusions: The results of our study indicate that we might able to predict the severity of CAD by measure of IR.


How to cite this article:
Srinivasan MP, Kamath PK, Manjrekar PA, Unnikrishnan B, Ullal A, Kotekar MF, Mahabala C. Correlation of severity of coronary artery disease with insulin resistance.North Am J Med Sci 2013;5:611-614


How to cite this URL:
Srinivasan MP, Kamath PK, Manjrekar PA, Unnikrishnan B, Ullal A, Kotekar MF, Mahabala C. Correlation of severity of coronary artery disease with insulin resistance. North Am J Med Sci [serial online] 2013 [cited 2020 Apr 8 ];5:611-614
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2013;volume=5;issue=10;spage=611;epage=614;aulast=Srinivasan;type=0