North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2013  |  Volume : 5  |  Issue : 1  |  Page : 41--46

Serum cholesterol and ceruloplasmin levels in second trimester can predict development of pre-eclampsia


Madhusudan Dey, Devendra Arora, Nagarja Narayan, Reema Kumar 
 Department of Obstetrics and Gynaecology, Armed Forces Medical Services, India

Correspondence Address:
Madhusudan Dey
40/41, First Floor, Monohar Kunj, Gautam Nagar, New Delhi - 110 049
India

Background: Pre-eclampsia is one of the leading causes of high rates of maternal and perinatal mortality and morbidity. Pathophysiology of pre-eclampsia is still obscure. Currently, there are no screening tests for pre-eclampsia that are reliable, valid, and economical. Parameters of oxidative stress could be early markers of endothelial dysfunction that predates clinical pre-eclampsia. Aim: This study was to study ceruloplasmin in nulliparous women as marker of oxidative stress and lipid profile to evaluate their value in prediction of pre-eclampsia. Materials and Methods: Prospective observational study. 306 nulliparous women had their serum lipid profile and ceruloplasmin levels measured at 14-16 weeks period of gestation as sample 1 and at 18-20 weeks as sample 2. All cases were followed up till the end of pregnancy for development of pre-eclampsia. Results: There was no statistically significant difference between the normals and pre-eclampsia cases at 14-16 week for all the oxidative stress parameters ( P > 0.05), but at 18-20 week, there was statistically significant difference between the normals and pre-eclampsia cases in cholesterol and ceruloplasmin parameters ( P < 0.05). Conclusion: Cholesterol and ceruloplasmin levels in second trimester (18-20 weeks) can predict the development of pre-eclampsia.


How to cite this article:
Dey M, Arora D, Narayan N, Kumar R. Serum cholesterol and ceruloplasmin levels in second trimester can predict development of pre-eclampsia.North Am J Med Sci 2013;5:41-46


How to cite this URL:
Dey M, Arora D, Narayan N, Kumar R. Serum cholesterol and ceruloplasmin levels in second trimester can predict development of pre-eclampsia. North Am J Med Sci [serial online] 2013 [cited 2020 Aug 14 ];5:41-46
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2013;volume=5;issue=1;spage=41;epage=46;aulast=Dey;type=0