North American Journal of Medical Sciences

REVIEW ARTICLE
Year
: 2015  |  Volume : 7  |  Issue : 8  |  Page : 341--346

Amplification of cellular oncogenes in solid tumors


Ozkan Bagci, Serkan Kurtgöz 
 Department of Medical Genetics, Suleyman Demirel University, School of Medicine, Isparta, Turkey

Correspondence Address:
Dr. Ozkan Bagci
Department of Medical Genetics, Suleyman Demirel University, Medical Faculty, Isparta
Turkey

The term gene amplification refers to an increase in copy number of a gene. Upregulation of gene expression through amplification is a general mechanism to increase gene dosage. Oncogene amplifications have been shown in solid human cancers and they are often associated with progression of cancer. Defining oncogene amplification is useful since it is used as a prognostic marker in clinical oncology nowadays, especially v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (HER2) targeted agents are used in breast cancer patients with high level of HER2 overexpression as a therapeutic approach. However, patients without HER2 overexpression do not appear to benefit from these agents. We concluded that determination of oncogene amplification in solid tumors is an important factor in treatment of human cancers with many unknowns. We have referred to PubMed and some databases to prepare this article.


How to cite this article:
Bagci O, Kurtgöz S. Amplification of cellular oncogenes in solid tumors.North Am J Med Sci 2015;7:341-346


How to cite this URL:
Bagci O, Kurtgöz S. Amplification of cellular oncogenes in solid tumors. North Am J Med Sci [serial online] 2015 [cited 2019 Sep 20 ];7:341-346
Available from: http://www.najms.org/article.asp?issn=1947-2714;year=2015;volume=7;issue=8;spage=341;epage=346;aulast=Bagci;type=0