Original Article                                                                                                                                                                                                                                                                                OPEN ACCESS

Gamma glutamyltransferase levels and its association with high sensitive C-reactive protein in patients with acute coronary syndromes

Mehmet Yunus Emiroglu, MD¹, Özlem Batukan Esen, MD², Mustafa Bulut, MD¹, Hekim Karapinar, MD³,

Zekeriya Kaya, MD¹, Mustafa Akcakoyun, MD¹, Ramazan Kargin, MD¹, Soe Moe Aung, MD¹,           

Elnur Alızade, MD¹, Selcuk Pala, MD¹, Ali Metin Esen, MD¹           

¹ Department of Cardiology, Kartal Kosuyolu Cardiovascular Research and Training Hospital, Istanbul, Turkey.

² Department of Cardiology, Memorial Hospital, Istanbul, Turkey.

³ Department of cardiology, Van Cardiovascular Research and Training Hospital, Van, Turkey.

Citation: Emiroglu MY, Esen ÖB, Bulut M, Karapinar H, Kaya Z, Akcakoyun M, Kargin R, Aung SM, Alızade E, Pala S, Esen AM. Gamma glutamyltransferase levels and its association with high sensitive C-reactive protein in patients with acute coronary syndromes. North Am J Med Sci 2010; 2: 306-310.    

Doi: 10.4297/najms.2010.2301

Availability: www.najms.org

ISSN: 1947 – 2714

Abstract

Background: Elevated Gamma-glutamyltransferase (GGT) level is independently correlated with conditions associatedwith increased atherosclerosis, such as obesity, elevated serum cholesterol, high blood pressure and myocardial infarction. It is also demonstrated that serum gamma-glutamyltransferase activity is an independent risk factor for myocardial infarction and cardiac death in patients with coronary artery disease. Although the relationship between gamma-glutamyltransferase and coronary artery disease has been reported, not many studies have shown the relationship between changes ofgamma-glutamyltransferase in acute coronary syndromes and a well established coronary risk factor high sensitive C-reactive protein. (hs-CRP). Aims: In this study, how gamma-glutamyltransferase levels changed in acute coronary syndromes and its relationship with high sensitive C-reactive protein if any were studied. Patients & Methods:This trial was carried out at Kosuyolu Cardiovascular Training and Research Hospital and Van Yuksek Ihtisas Hospital, Turkey. 219 patients (177 males and 42 females) presenting with acute coronary syndrome, and 51 control subjects between September 2007 and September 2008 were included in the study. Serum gamma-glutamyltransferase, high sensitive C-reactive protein, serum lipoprotein levels and troponin I were determined. Results: Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients compared to control. There was also correlation between gamma-glutamyltransferase and high sensitive C-reactive protein levels. Conclusion: Serum gamma-glutamyltransferase and high sensitive C-reactive protein levels were higher in acute coronary syndrome patients. In subgroup analyses, the higher difference with Non-ST elevation myocardial infarction and ST elevation myocardial infarction groups than unstable angina oectoris group proposes a relationship between gamma-glutamyltransferase and severity of acute coronary syndromes.

Keywords: Gamma-glutamyltransferase, high sensitive C-reactive protein, acute coronary syndrome.

Correspondence to: Mehmet Yunus Emiroglu, MD, Kaynarca District, Sevgi Street, Gulistanbul Apt. No.16 Pendik, Istanbul, Turkey. Tel.: +90 541 565 33 22, Email: yunusemiroglu@hotmail.com