Original Article   OPEN ACCESS

Familial early onset of type-2 diabetes mellitus and its complications

1Diabetes Centre & Department of Medicine, 2Community Medicine, 3Paediatrics and 4Biochemistry, K.L.E.S Dr. Prabhakar  Kore Hospital & Medical Research Centre & Jawaharlal Nehru Medical College, KLE University, Belgaum- 590010, Karnataka, India.

Citation: Jali MV, Kambar S, Jali SM, Gowda S. Familial early onset of type-2 diabetes mellitus and its complications. North Am J Med Sci 2009; 1: 377-380.    
Doi: 10.4297/najms.2009.7377
Availability: www.najms.org
ISSN: 1947 – 2714

Background: Globally, the prevalence of chronic, non-communicable diseases is increasing at an alarming rate. Furthermore, approximately 197 million people worldwide have impaired glucose tolerance. Consequently, diabetes is rapidly emerging as a global health problem that threatens to assume a pandemic level by 2030. In Indian population, genetic predisposition to trigger diabetes at an early age as compared to western counterpart has been focused very much. Aim: To gain further insight into the positive correlation between the diabetes and family history was the objective of this study. Materials and Methods: Patients attending the Diabetes Centre, K.L.E.S Dr. Prabhakar. Kore Hospital and Medical Research Centre; J. N. Medical College; KLE University Belgaum, Karnataka- India, were recruited, diagnosed and analyzed as per WHO criteria. Results: The prevalence of diabetes was higher among patients with diabetic mother (25.6%) compared to patients with diabetic father (21.2%) and there was early onset of type -2 diabetes among patients having both parents with diabetic when compared to other patients. Conclusion: Based on the present observation, it would be appropriate to emphasize again that a strong family history for diabetes, would signal at an early age, the onset of diabetes perhaps with its complications.

Keywords: Family history, type-2 diabetes mellitus, retinopathy, nephropathy.

Correspondence to: Dr. Mallikarjun V Jali, Chief Diabetologist, Diabetes Centre, Medical Director & CEO, K. L. E. Society's Dr Prabhakar Kore Hospital & Medical Research Centre (An affiliate of KLE University). Professor, Department of Medicine, J.N. Medical College, Belgaum 590010, Karnataka, India. Tel.: +91 831 2473777, Fax: +91 831 2470732. Email: drmvjali@gmail.com