Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Reader Login
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 89
Export selected to
Endnote
Reference Manager
Procite
Medlars Format
RefWorks Format
BibTex Format
  Citation statistics : Table of Contents
   2012| October  | Volume 4 | Issue 10  
    Online since October 4, 2012

 
 
  Archives   Previous Issue   Next Issue   Most popular articles   Most cited articles
 
Hide all abstracts  Show selected abstracts  Export selected to
  Cited Viewed PDF
ORIGINAL ARTICLES
Ocular pseudoexfoliation and cardiovascular disease: A national cross-section comparison study
Dustin D French, Curtis E Margo, Lynn E Harman
October 2012, 4(10):468-473
DOI:10.4103/1947-2714.101987  PMID:23112968
Background: Pseudoexfoliation is a systemic disorder characterized by the deposition of extracellular matrix material. The microfibrillar material that gives rise to the condition is visible clinically in the anterior segment of the eye, and is also found in other tissues, including blood vessels, skin, gallbladder, kidneys, lungs, and heart. Aims: The present study aims to determine whether ocular pseudoexfoliation is associated with selected cardiovascular diseases. Materials and Methods: A cross-section comparison study was conducted with the help of the Veterans Health Administration databases, using the International Classification of Diseases, Ninth revision, Clinical Modification for pseudoexfoliation of lens capsule and pseudoexfoliation glaucoma. Selected cardiovascular diseases and risk factors for cardiovascular disease were identified using the appropriate medical codes. Patients with primary open-angle glaucoma, chronic sinusitis, and benign prostatic hyperplasia served as the comparison groups. A logistic regression model was used to control for age, gender, race, and major cardiovascular risk factors. Results: There were 6,046 case patients with pseudoexfoliation; approximately half were diagnosed with pseudoexfoliation glaucoma. Various stages of ischemic heart disease, cardiomyopathy, and aortic aneurysm were significantly associated with ocular pseudoexfoliation, after controlling for age, gender, race, and major cardiovascular risk factors. Associations, in general, were less demonstrable relative to the primary open-angle glaucoma comparison group. Conclusion: Associations of ocular pseudoexfoliation with cardiovascular diseases were generally fewer and less pronounced when compared to patients with primary open-angle glaucoma. These results add to the results of earlier studies, which suggest that open-angle glaucoma itself might be a risk factor for certain cardiovascular disorders.
  26 2,734 335
REVIEW ARTICLES
Physiological effects of yogic practices and transcendental meditation in health and disease
PA Balaji, Smitha R Varne, Syed Sadat Ali
October 2012, 4(10):442-448
DOI:10.4103/1947-2714.101980  PMID:23112963
Yoga is an ancient Indian way of life, which includes changes in mental attitude, diet, and the practice of specific techniques such as yoga asanas (postures), breathing practices (pranayamas), and meditation to attain the highest level of consciousness. Since a decade, there has been a surge in the research on yoga, but we do find very few reviews regarding yogic practices and transcendental meditation (TM) in health and disease. Keeping this in view, a Medline search was done to review relevant articles in English literature on evaluation of physiological effects of yogic practices and TM. Data were constructed; issues were reviewed and found that there were considerable health benefits, including improved cognition, respiration, reduced cardiovascular risk, body mass index, blood pressure, and diabetes. Yoga also influenced immunity and ameliorated joint disorders.
  26 12,576 2,351
ORIGINAL ARTICLES
Comparison of size 2.5 i-gel TM with proseal LMA TM in anaesthetised, paralyzed children undergoing elective surgery
Subhro Mitra, Bikramjit Das, Shahin N Jamil
October 2012, 4(10):453-457
DOI:10.4103/1947-2714.101983  PMID:23112965
Background : The newest variation of i-gel is its pediatric version. This novel supraglottic airway device has the added advantage of a drain tube. In this study, we compared the effectiveness of size 2.5 i-gel with size 2.5 ProSeal LMA. Aims : This study was designed to investigate the usefulness of the size 2.5 i-gel compared with the ProSeal laryngeal mask airway (PLMA) of the same size in anesthetized, paralyzed children. Materials and Methods : Sixty ASA grade I - II patients undergoing elective surgery were included in this prospective study and were randomly assigned to the i-gel and PLMA groups (30 patients in each group). A size 2.5 supraglottic airway was inserted according to the assigned group. We assessed the ease of insertion, hemodynamic data, oropharyngeal sealing pressure, and postoperative complications. Results : There were no differences in the demographic and hemodynamic data, success rates for the first attempt of insertion, or postoperative airway morbidity among the two groups. The airway leak pressure of the i-gel group (27.12 ± 1.69 cmH 2 O) was significantly higher than that of the PLMA group (22.75 ± 1.46 cmH 2 O). Conclusion : Hemodynamic parameters, ease of insertion and postoperative complications were comparable between the i-gel and PLMA, but the nairway sealing pressure was significantly higher in the i-gel group.
  10 2,198 383
REVIEW ARTICLES
Molecular biology of gallbladder cancer: Potential clinical implications
Ĺke Andrén-Sandberg
October 2012, 4(10):435-441
DOI:10.4103/1947-2714.101979  PMID:23112962
Gallbladder cancer (GBC) is a common malignancy of the biliary tract and involves the changes in multiple oncogenes and multiple genetic genes. Since over the past decade there has been an advance in the knowledge of the genetic basis of cancer, mainly as a result of the rapid progression of molecular technology; however, conventional therapeutic approaches have not had much impact on the course of this aggressive neoplasm. Knowledge of the molecular biology of GBC is rapidly growing. Genetic alterations in GBC include adenosine triphosphate-binding cassette transporter ABCG8, membrane-bound enzyme ADAM-17 of multi-functional gene family, and other genes including p53, COX2, XPC, and RASSF1A. The advances in molecular biology have potential implications for the detection of this disease, using Synuclein-gamma, Syndecan-1, glycoprotein 72 (TAG-72), tumor endothelial marker 8 protein (TEM8) and TNF-alpha. The use of these molecular diagnostic methods is of clinical importance for the gene replacement therapy, genetic prodrug activation therapy, and antisense immunology technology for the treatment of malignancy. The author reviewed recent publications on PubMed, and summarized molecular biology of GBC, with an emphasis on features of potential clinical implications for diagnosis and management.
  8 1,576 322
ORIGINAL ARTICLES
Prediction of clinical outcome in acute hemorrhagic stroke from a single CT scan on admission
Chiranjib Nag, Kamalesh Das, Mrinalkanti Ghosh, MR Khandakar
October 2012, 4(10):463-467
DOI:10.4103/1947-2714.101986  PMID:23112967
Background: From a single CT scan in primary intracerebral hemorrhage (ICH), clinical outcome can be assessed on admission by using the CT scan parameters. Aims: The study aims to find out how hematoma volume, location of stroke, midline shift, intraventricular extension of bleed and ventricle compression influence the clinical outcome in patients with acute ICH. Materials and Methods: Non-contrast CT scan was done on admission in hospital for every patient with acute hemorrhagic stroke and was analyzed accordingly. Clinical assessments were done in National Institute of Health Stroke Scale (NIHSS). Chi-square test and multiple logistic regression analysis were used for statistical analysis. Results: Mean hematoma volume associated with death before 30 days is 33.16 cm3 (P < 0.0001), with survived after 30 days is 15.45 cm3 (P < 0.0001), with NIHSS score 16 is 29.03 cm3 (P < 0.0001) and with NIHSS score <16 is 13.69 cm3 (P < 0.0001). Independent poor prognostic factors were hematoma volume > 30 cm3 (OR = 27.857), brain stem hemorrhage (OR = 6.000), intraventricular extension of bleed from other location (OR = 7.846), presence of ventricular compression alone (OR = 2.700) and in combination with midline shift of 5 mm (OR = 2.124). Conclusions: From a single CT scan during hospital admission, mortality and morbidity in next 30 days can be predicted. A hematoma volume >30 cm3, brain stem hematoma, intraventricular extension of bleed and ventricular compression along and with midline shift are associated with early mortality in ICH.
  7 3,391 448
Malarial hepatopathy and its outcome in India
Rama Prakasha Saya, Goswami Debabrata, Ganesh Kumar Saya
October 2012, 4(10):449-452
DOI:10.4103/1947-2714.101981  PMID:23112964
Background: Jaundice in Plasmodium falciparum malaria is multifactorial and its incidence varies in different regions. It is important to assess the incidence and factors associated with malarial hepatopathy as well as its complications to understand the pattern of disease presentation in order to undertake appropriate interventional measures. There is a paucity of data with regard to malarial hepatopathy and its outcome at the global level. Aim: The study was conducted to assess the pattern, spectrum of biochemical parameters and complications of hepatopathy related to P. falciparum malaria. Materials and Methods: A descriptive study was conducted in a tertiary care hospital attached to a government medical institution in Assam, India. Demographic details of the hundred patients with P. falciparum malaria, their clinical and biochemical parameters, complications and outcome were collected using a prestructured proforma. Data was compared using proportion and Chi Square test. Results: The proportion of those with malarial hepatopathy was 38% and the incidence was more in males and younger age group. The degree of hyperbilirubinemia, complications that include renal failure, shock, acute respiratory distress syndrome, hypoglycemia and mortality were significantly more among patients with hepatopathy (P<0.05). Conclusion: Malarial hepatopathy is associated with a higher incidence of complications like renal failure, shock, acute respiratory distress syndrome and hypoglycemia. Further studies are required to elucidate the factors associated with malarial hepatopathy and to prevent the complications and mortality.
  7 2,506 521
Social determinants and its influence on the prevalence of morbidity among adolescent girls
Beena Sachan, MZ Idris, Savita Jain, Reema Kumari, Ashutosh Singh
October 2012, 4(10):474-478
DOI:10.4103/1947-2714.101990  PMID:23112969
Background: The adolescent girls are more vulnerable, particularly in developing countries including India, due to various adverse socio-cultural and economic reasons. Majority of the health problems affecting adolescent girls are preventable by promotion of hygienic practices through proper health education by the teachers. Aim: This study was designed to examine the various factors influencing the prevalence of morbidity among school-going adolescent girls of Lucknow district in north India. Materials and Methods: A cross-sectional study was carried out in urban and rural schools of Lucknow district from 2008 to 2009. Multistage random sampling was used to select the requisite number of girls. A total of 847 adolescent girls between 10 and 19 years of age were interviewed, and information regarding their socio-demographic characteristics was collected and clinical examination was carried out. Statistical analyses were done using percentage and Chi-square test. Results: Of 847 adolescent girls, around 64.8% were found to be sick at the time of the study. Significant association of morbidity was observed with caste, birth order, type of family, socioeconomic status (SES), living status with parents/guardian, and general personal hygiene (P<0.05). Conclusion: This study reveals a high prevalence of morbidity. A strong need exists for planning and programming intervention activities for health needs in the area.
  6 2,097 299
Photogrammetric analysis of palpebral fissure dimensions and its position in Malaysian south Indian ethnic adults by gender
P Vasanthakumar, Pramod Kumar, KG Mohandas Rao
October 2012, 4(10):458-462
DOI:10.4103/1947-2714.101984  PMID:23112966
Background: Anthropometric data describing the palpebral fissure and its position is available for various populations. Unfortunately there is no data available for Malaysian South Indian. Aim: The present study was undertaken to determine the normative values for Malaysian South Indian according to gender. Materials and Methods: Anthropometric measurement was done on standardized photographs taken from 300 MSI aged 18-26 years. The parameters were measured using computerized software. Results: Significant sexual difference was observed in all parameters except canthal index, which includes palpebral fissure width (male, 30.9 mm; female, 29.62 mm), palpebral fissure height (male, 11.06 mm; female, 11.48 mm), palpebral fissure inclination (male, 4.72°; female, 7.04°), outercanthal distance (male, 97.15 mm; female, 91.78 mm), interpupillary distance (male, 68.09 mm; female, 63.6 mm), intercanthal distance (male, 34.1 mm; female, 32.77 mm), and canthal index (male, 35.22 mm; female, 35.86±4.44 mm). Conclusions: Sexual dimorphism was found in all parameters. Comparison of our results with other studies revealed the variation and similarities in key parameters. Establishing normative values and understanding the facial morphology of different ethnic groups is important in designing the treatment planning for an aesthetic oculoplastic procedure.
  4 2,602 302
RESEARCH LETTERS
Clinical correlates and outcome of Shoshin Beriberi
Rama Prakasha Saya, Shashidhar Baikunje, Parampalli Suryanarayana Prakash, Kodangala Subramanyam, Vikram Patil
October 2012, 4(10):503-506
DOI:10.4103/1947-2714.102003  PMID:23112976
  4 2,106 375
ORIGINAL ARTICLES
Molecular detection of Pneumocystis jirovecii in patients with respiratory tract infections
Oyebode Armstrong Terry Alli, David Olusoga Ogbolu, Olufunmi Ademola, Musiliu Adewale Oyenike
October 2012, 4(10):479-485
DOI:10.4103/1947-2714.101993  PMID:23112970
Background: Pneumocystis jirovecii, formerly known as P. carinii, is an opportunistic fungus causing Pneumocystis carinii pneumonia especially in immunocompromised patients. Aim: The aim of this study was to detect P. jirovecii in sputum samples from patients suspected of having respiratory tract infections. Materials and Methods: In this study, 230 acid fast bacilli negative sputum samples from 230 patients presenting with respiratory tract infections submitted to three teaching hospitals' medical microbiology laboratories in Osun and Oyo States, Nigeria for routine investigation were examined for P. jirovecii by microscopical and polymerase chain reaction methods. Results: P. jirovecii cysts were observed in 15 (6.5%) samples and polymerase chain reaction was positive for 29 (12.6%) samples out of 230 samples examined. It was observed that the detection of P. jirovecii was associated with age (P < 0.05) while there were no associations between diagnosis, sex, and prevalence of P. jirovecii (P > 0.05). Polymerase chain reaction was showed to be a better method for the detection of P. jirovecii based on the 51.7% sensitivity and 100% specificity of the microscopy. Conclusion: The study concluded that P. jirovecii is prevalent in patients with respiratory tract infections in hospitals from the southwestern part of Nigeria and should be included in diagnosis of these infections in this part of the world.
  3 1,734 320
LETTERS TO EDITOR
Austrian syndrome and multiple myeloma: A fatal combination
Abdur Baig, Manfred Moskovits, Edmund M Herrold, Sonia Borra
October 2012, 4(10):516-519
DOI:10.4103/1947-2714.102014  PMID:23112981
  1 1,594 205
RESEARCH LETTERS
Clinical and bacteriological aspects of pyoderma
Shashi Gandhi, AK Ojha, KP Ranjan, Neelima
October 2012, 4(10):492-495
DOI:10.4103/1947-2714.101997  PMID:23112973
  1 1,864 345
Association between serum gamma-glutamyl transferase level and hypertension in Indian adults: A population based cross-sectional study
Subhasish Dan, Indranil Banerjee, Himangshu Roy, Shiuli Roy, Tamoghna Jana, Satrajit Dan
October 2012, 4(10):496-498
DOI:10.4103/1947-2714.102000  PMID:23112974
  1 1,314 221
Phosphodiesterase-III inhibitors amrinone and milrinone on epilepsy and cardiovascular activities
Mohammad Asif
October 2012, 4(10):499-502
DOI:10.4103/1947-2714.102001  PMID:23112975
  1 1,712 256
CASE REPORT
CD45/CD8 myeloid histioid antigen and plasma cell antibody immune response in a case of malignant melanoma
Ana Maria Abreu-Velez, Michael S Howard, Neville Y Pereyo, Keith A Delman, Martin C Mihm, Monica Rizzo
October 2012, 4(10):507-509
DOI:10.4103/1947-2714.102006  PMID:23112977
The immune response in metastatic melanoma is not well established and therefore is of particular interest to test for recruitment of immune cells to the tumor. A 46-year-old Caucasian female was evaluated for an asymptomatic right forearm mass. The lesion had been present for at least 4 years and had become painful 4 months ago. Biopsies for hematoxylin and eosin (H and E) staining, as well as immunohistochemical analysis were performed on the primary tumor and on sentinel lymph nodes. The H and E staining was consistent with metastatic melanoma. Positive staining was noted on the tumor cells with S-100, Mart-1/Melan A/CD63, PNL2, HMB45, and tyrosinase. Peritumoral and intratumoral inflammatory cells stained positive for CD8, CD45, PCNA, myeloid histoid antigen, antihuman plasma cell antibody, and focal BRCA1. The staining patterns of CD8/CD45, myeloid histoid antigen and plasma cell antibody on inflammatory cells around the melanoma cells suggest an unusual type of immune response.
  - 1,590 244
COMMENTARY
Pneumocystis Jirovecii pneumonia in Africa: Impact and implications of highly sensitive diagnostic technologies
Olga Matos
October 2012, 4(10):486-487
PMID:23112971
  - 1,131 204
LETTERS TO EDITOR
Multifocal epithelial hyperplasia
Amilcar Méndez-Mendoza, Constantino Ledesma-Montes, Maricela Garcés-Ortíz
October 2012, 4(10):510-511
DOI:10.4103/1947-2714.102008  PMID:23112978
  - 621 105
Spontaneous pregnancy and unexplained infertility: A gift with many whys
Ilaria Soave, Giuseppe Lo Monte, Roberto Marci
October 2012, 4(10):512-513
DOI:10.4103/1947-2714.102010  PMID:23112979
  - 1,268 225
Factors associated with organ donation
Darpan Kaur, Shaunak Ajinkya
October 2012, 4(10):514-515
DOI:10.4103/1947-2714.102011  PMID:23112980
  - 1,533 287
Hydranencephaly: A rare cause of an enlarging head size in an infant
Mohd Khalid, Saifullah Khalid, Samreen Zaheer, Navneet Redhu, Ekramullah
October 2012, 4(10):520-522
DOI:10.4103/1947-2714.102015  PMID:23112982
  - 2,406 344
RESEARCH LETTERS
Mobile radiofrequency does not interfere with antiarrhythmic drugs in patients with ischemic heart disease
Adil H Alhussieny, Marwan S M Al-Nimer, Amer D Majeed
October 2012, 4(10):488-491
DOI:10.4103/1947-2714.101996  PMID:23112972
  - 1,512 222
Feedback
Subscribe