Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 578
ORIGINAL ARTICLE
Year : 2011  |  Volume : 3  |  Issue : 4  |  Page : 176-178

No association between Val158Met of the COMT gene and susceptibility to schizophrenia in the Syrian population


1 Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
2 Department of Pharmacology, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
3 Department of Biochemistry, Faculty of Pharmacy, University of Aleppo, Aleppo, Syria
4 Ibn Khaldoon Psychiatric Hospital, Aleppo, Syria
5 Academic Psychiatry, Newcastle General Hospital, Newcastle NE4 6BE, United Kingdom

Correspondence Address:
Bassam Lajin
Department of Analytical Chemistry, Faculty of Pharmacy, University of Aleppo, Aleppo
Syria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


Rights and PermissionsRights and Permissions

Background : The Val158Met single nucleotide polymorphism of the COMT gene has been implicated in the aetiology of schizophrenia, although results from different populations have been conflicting. Aims: The aim of the present study was to investigate possible association between schizophrenia and Val158Met in a novel Arab population from Syria. Methods and Materials: 71 unrelated schizophrenic subjects (45 men) and 102 unrelated healthy controls (62 men) were recruited to take part in this case- control study. The Val158Met of the COMT gene was genotyped for patients and controls, using a new optimized PCR-RFLP method. Results: the results demonstrated that there is no statistically significant difference between the two groups. Conclusion: This study does not support that Val158Met has an influence on susceptibility for schizophrenia in this population.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed1419    
    Printed91    
    Emailed0    
    PDF Downloaded302    
    Comments [Add]    

Recommend this journal