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 Table of Contents  
Year : 2012  |  Volume : 4  |  Issue : 4  |  Page : 163-169

Antibiotic susceptibility patterns of urinary pathogens in female outpatients

1 Department of Pharmacology, Rohilkhand Medical College and Hospital, Bareilly, India
2 Department of Obstetrics and Gynaecology, Era's Lucknow Medical College, Sarfarazganj, Lucknow, India
3 Department of Community Medicine, Rohilkhand Medical College and Hospital, Bareilly, India
4 Department of Medicine, Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow, Uttar Pradesh, India

Date of Web Publication11-Apr-2012

Correspondence Address:
Syed Esam Mahmood
Department of Community Medicine, Rohilkhand Medical College and Hospital, Bareilly - 243 006, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/1947-2714.94940

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Background: Urinary tract Infection (UTI) is among the most common infections described in outpatient setting and hospital patients. In almost all cases empirical antimicrobial treatment initiates before the laboratory results of urine culture are available; thus antibiotic resistance may increase in uropathogens due to frequent use of antibiotics. Aims: The study was designed to find the prevalence of UTI in females with urinary tract symptoms, to determine the causative organism (s) of UTI, and to determine the antibiotic susceptibility pattern of microbial agents isolated from urine culture (antibiogram). Materials and Methods: The prospective, observational study involved 139 females, aged 15 years and above clinically suspected for UTI attending outpatient Departments of Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow. A structured questionnaire was used to interview the study subjects. A chi-square test and Fisher Exact test were used to analyze data. Results: The overall prevalence of UTI was found to be 45.32% (63/139). Escherichia coli (33.1%) and Klebsiella pneumoniae (7.9%) were the most common organisms isolated. The most effective antibiotic for both was Nitrofurantoin. Conclusions: Regular monitoring is required to establish reliable information about susceptibility pattern of urinary pathogens for optimal empirical therapy of patients with UTI.

Keywords: Antimicrobial susceptibility patterns, Prevalence, Urinary tract infections

How to cite this article:
Shaifali I, Gupta U, Mahmood SE, Ahmed J. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North Am J Med Sci 2012;4:163-9

How to cite this URL:
Shaifali I, Gupta U, Mahmood SE, Ahmed J. Antibiotic susceptibility patterns of urinary pathogens in female outpatients. North Am J Med Sci [serial online] 2012 [cited 2023 Apr 2];4:163-9. Available from: https://www.najms.org/text.asp?2012/4/4/163/94940

  Introduction Top

Urinary tract Infection (UTI) is one of the most common clinical syndromes encountered in general and gynecological practices. [1] They are among the most common infections described in outpatients setting and hospital patients. [2],[3] Adult women (40-50%) have a history of at least one episode of UTI in their lifetime . The incidence of UTI among women rises by 5% per decade. There is an increase in UTI during pregnancy by about 7%. [4] UTIs may be community acquired or nosocomial. Community acquired infection is caused by Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus saprophyticus or Enterococcus faecalis, while the hospital acquired ones are Escherichia coli, Pseudomonas aeruginosa, Proteus sp, Enterobacter sp., Serratia sp. or Enterococcus.

UTI is a broad term that encompasses asymptomatic bacteriuria and symptomatic infection with microbial invasion and inflammation of the urinary tract . While up to 90% of the patients with UTIs complain of urinary tract symptoms, one third or more of the patients with these symptoms do not have bacteriuria. [5] The most common symptoms for which most patients seek treatment are dysuria and frequency. Dysuria and frequency together raise the probability of UTI to more than 90%, effectively ruling in the diagnosis by history alone. [6] In almost all cases of UTI, empirical antimicrobial treatment initiates before the laboratory results of urine culture are available; thus antibiotic resistance may increase in uropathogens due to frequent use of antibiotics. [7] Increasing resistance in bacterial pathogens is of world-wide concern. The prevalence of antimicrobial resistance in patients with UTI is increasing and can vary according to geographical and regional location. [8]

For this reason, knowledge of the etiological agents of UTIs and their antimicrobial resistance patterns in specific geographical locations may aid clinicians in choosing the appropriate antimicrobial empirical treatment. The literature on prevalence of UTI among females in Lucknow was scarce in recent decades; thereby the present study was undertaken to find out the prevalence of UTI and to determine the antimicrobial susceptibility patterns of commonly used antibiotics among females in Lucknow.

  Materials and Methods Top

This observational, prospective 12 months' study was carried out among out patient departments of Obstetrics and Gynaecology and Medicine of Vivekananda Polyclinic and Institute of Medical Sciences, Lucknow after ethical clearance from the institution review board. All females aged 15 years and above attending the respective outpatient departments clinically suspected for UTI were selected for the purpose of the study during the study period. The total number of females surveyed was 139. Patients who had no symptoms suggestive of UTI at the time of observation were excluded from the study. Females suffering from diabetes mellitus, renal disorders, HIV positivity, or on corticosteroid therapy were also excluded. Those females who did not give consent were noncooperative or refused to provide the necessary information were not included in the study.

The necessary information was collected using the interview technique from each respondent after informed consent. A structured questionnaire was used to assess the study subjects' self-reported information regarding socio-demographic characteristics and urinary symptoms. Data regarding organisms causing UTI and their antibiotic sensitivity patterns were collected.

All study subjects were advised to collect the mid-stream urine sample in wide-mouthed sterile containers. They were instructed to clean the area around the urethral opening with clean water, dry the area, and collect the urine with the labia held apart. Samples were processed within 1 hour of collection. For direct microscopy (wet film preparation) 50 μl of well-mixed uncentrifuged urine was taken on a slide and a cover slip placed on it. It was viewed under a high-power objective. The presence of one pus cell/7 hpf was considered significant pyuria. [9]

Jensens modification of gram staining was employed. At least 20 fields were examined and detection of one or more morphologically similar bacteria per oil immersion field was treated as significant. A mixture of E. coli and Staphylococcus aureus was used as a positive control and uninoculated broth as negative control. The presence of more than two morphologically different organisms indicated the presence of mixed flora.

For urine culture the urine sample (1 μl) was inoculated on cysteine lactose electrolyte deficient medium, using a standard loop of internal diameter 1.34 mm (semiquantitative method). The plates were read after 24 hours of aerobic incubation at 37°C. They were further incubated for another 24 hours before a negative report was issued. A single organism obtained in counts of >100,000 cfu/ml was further identified by standard biochemical techniques. [9]

The agar diffusion technique was used for antibiotic susceptibility testing. [9] Five colonies of the test organisms were streaked on agar plates using a sterile inoculating wire loop. The appropriate multidisk depending on whether the test organism plated will be gram negative or gram positive was then placed firmly onto the surface of the dried plates, using sterile forceps. The plates were left at room temperature for 1 hour to allow diffusion of the different antibiotics from the disk into the medium. The plates were further incubated at 37° C for 18-24 hours. Interpretation of results was done using the zone sizes. The zone of inhibition of greater than 10 mm was considered sensitive, 5-10 mm as moderately sensitive and no zone of inhibition as resistant.

The antibiotics tested were Amoxicillin, Ampicillin, Ampicillin-Sulbactam, Piperacillin, Cloxacillin Tazobactam, Cephalexin, Cefadroxil, Cefaclor, Cefuroxime, Cefixime, Cefotaxime, Cefoperazone, Ceftazidine, Ceftizoxime, Ceftriaxone, Cefepime, Nalidixic acid, Ciprofloxacin, Lomefloxacin, Norfloxacin, Pefloxacin, Ofloxacin, Nitrofurantoin, Tetracycline, Co-trimaxazole, Clarithromycin, Roxithromycin, Erythromycin, Amikacin, Gentamicin, Tobramycin, Netilmicin, Kanamycin.

Data analysis was performed using the SPSS windows version 14.0 software. Tests of significance like Pearson's chi-square test and Fisher Exact test were applied to find out the results. A value of P<0.05 was considered statistically significant.

Following Operational Definitions [9] were put to use in the present study:

  • Microscopy findings of more than 10 WBC per high power field were considered significant.
  • Significant bacteriuria was defined as culture of a single bacterial species from the urine sample at a concentration of more than 100,000 cfu/ml.

  Results Top

Five females suffering from diabetes mellitus, renal disorders, HIV positivity, or on corticosteroid therapy were also excluded. Two females who did not give consent, were noncooperative or refused to provide the necessary information were not included in the study. Thus total number of females surveyed was 139. The overall prevalence of UTI was found to be 45.32% (95% confidence interval, 37.52-53.12). Overall 46.87% of 96 urban respondents and 41.86% of 43 rural respondents were identified with UTI. Thirty-two (51.61%) of 62 females aged between 25 and 34 years and 15 (46.87%) of 32 females aged between 15 and 24 years were identified with UTI. Ten (40.0%) of 25 females between 35 and 44 years and 6 (30.0%) of 20 females above 45 years of age had UTI. Five (26.31%) of 19 illiterate females were identified with UTI and 58 (48.33%) of 120 literate females had UTI. Fifty-six (44.09%) homemakers and six (66.67%) students were identified with UTI [Table 1].
Table 1: Distribution of respondents according to their socio-demographic and clinical characteristics

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The most common urinary symptom presented was burning micturition (73.4%) followed by frequency (43.9%), urgency (20.9%), painful voiding (20.1%), difficulty (5.0%), and nocturnal incontinence (1.4%).

Ten (50.0%) of 20 pregnant females had UTI compared to 53 (44.53%) of 119 nonpregnant females.

Out of the 63 pathogens, E. coli (33.1%) was the most common organism isolated followed by Klebsiella pnuemoniae (7.9%), Staphylococcus aureus (2.2%), Streptococcus pnuemoniae (1.4%), and Proteus mirabilis (0.7%), respectively.

The most effective antibiotic for the E. coli isolates observed was Nitrofurantoin (86.95%) followed by Amoxicillin (69.56%), Nalidixic acid (65.21%), and Cotrimoxazole (60.86%). High efficacy of Nitrofurantoin (90.90%) followed by Cotrimoxazole and Tetracycline (81.81%) both was observed against the Klebsiella isolates. Cephalexin, Cefaclor, Nalidixic acid, and Norfloxacin also showed similar higher efficacies (72.72%) for Klebsiella isolates. Amoxicillin, Ampicillin-Sulbactam, Cefixime, Pefloxacin, and Ciprofloxacin also showed similar susceptibilities (63.63%) for Klebsiella isolates. High susceptibility (100%) for Ampicillin, Nitrofurantoin, and Tetracycline was observed among the identified Proteus isolates. Cefixime and Nalidixic acid were highly effective (100.0%) for Staphylococcus aureus. Norfloxacin was also found effective (66.66%) for Staphylococcus aureus isolates. High susceptibility patterns to Nalidixic acid, Clarithromycin, Cotrimaxazole, Cefixime, Cephalexin, and Cefaclor (100.0%) followed by Nitrofurantoin (66.66%) among the Streptococcus isolates identified were observed. Ceftriaxone, Cefepime, Cefuroxime, Ceftizoxime, Gatifloxacin, Gentamicin, Tetracycline, and Erythromycin showed similar efficacies (50.0%) for Streptococcus isolates [Table 2]a and b.
Table 2:

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  Discussion Top

It is stated that UTI is predominantly a disease of the females due to a short urethra and proximity to vestibule and the anal opening. In our study too, out of the 139 females studied, 63 (45.32%) females were found to be urine culture positive. Similar findings were reported by Khan et al., in Aligarh. [10] Forty five (46.87%) out of 96 urban respondents and 18 (41.86%) out of 43 rural respondents were identified with UTI in our study. This may be attributed to the higher levels of awareness and treatment seeking behavior in the urban respondents compared to the rural respondents.

In our study, the prevalence of UTI was higher among the females aged between 15 and 44 years compared to those aged above 45 years of age. More cases of UTIs were recorded among young and middle age patients (20-49 years, 51.04%) by Akram et al. [11] In another study by Farhat Ullah et al., middle-aged patients accounted for 54.3% of UTI. [12] A higher percentage of literate females were identified with UTI compared to the literate ones in the current study. This may be due to the high treatment seeking behavior of the infected literates compared to illiterate ones.

In the present study the most common urinary symptom presented was burning micturition followed by frequency, urgency, and painful voiding. Similar trends have been reported by Medina-Bambardo et al. [5]

The percentage of pregnant females with UTI was found to be slightly higher than the nonpregnant infected females in our study. This is similar to the study by Khan et al., where out of 61 infected young women, 52 (86.8%) were found in their early or late phases of pregnancy. [10]

E. coli and Klebsiella pnuemoniae were the most common organisms isolated in our study. These findings agree with other recent Indian reports which have indicated that gram-negative bacteria, mostly E. coli and Klebsiella pneumoniae, are the most common pathogens isolated in patients with UTI [Table 3].
Table 3: Distribution of pathogens isolated among UTI patients

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The most effective antibiotic for E. coli in this study observed was Nitrofurantoin followed by Amoxicillin, Nalidixic acid, and Co-trimaxazole. This is similar to recent studies in India [Table 4]. The antimicrobial susceptibility pattern of E. coli varies widely by region. High efficacy of Nitrofurantoin followed by Co-trimaxazole and Tetracycline both was observed against Klebsiella in this study. Cephalexin, Cefclor, Nalidixic acid, Norfloxacin, Amoxicillin, Ampicillin-Sulbactum, Cefexime, Pefloxacin, and Ciprofloxacin were also effective for Klebsiella. Similar trends were reported by Kothari et al., and Savas et al. [17],[19] However Klebsiella isolates showed higher susceptibility against Imipenem (88%) and Amikacin (59%) in the study by Akram et al. [11]
Table 4: Regional antibiotic susceptibilities of E. coli isolates

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High susceptibility for Ampicillin, Nitrofurantoin, and Tetracycline was observed among the identified Proteus isolates in our study, whereas Proteus spp. showed the highest sensitivity to Ciprofloxacin (71.2%) in the study by Kashef et al., in Iran. [24] The present study revealed that Cefexime and Nalidixic acid were highly effective for Staphylococcus aureus. Whereas, all Staphylococcus aureus isolates were found to be susceptible against Imipenem, Ceftriaxone, and Cefotaxime by Akram et al. [11] Streptococcus was found susceptible to Nalidixic acid, Clarithromycin, Cotrimaxazole, Cephalosporins, Nitrofurantoin Gatifloxacin, Gentamycin, Tetracycline, and Erythromycin in our study. High susceptibility to aminoglycosides was also obvious in the study by Adedeji et al., in Yola. [25]

As we could not find similar studies, we used references of different field populations to compare our results. Those who visited Gynaecology consultation may have a different pretest probability of UTI than those who attended other hospital services or general practice consultations, and microbiological results can be also different.

  Conclusions Top

This reflects the need for accurate and updated population surveillance data, particularly in light of concerns regarding variable regional antimicrobial susceptibility patterns. This information will directly affect selection of empiric therapy for UTI. Regular monitoring is required to establish reliable information about susceptibility pattern of urinary pathogens for optimal empirical therapy of patients with UTIs. We suggest that empirical antibiotic selection should be based on the knowledge of local prevalence of bacterial organisms and antibiotic sensitivities rather than on universal guidelines. IEC messages for all the UTI patients must include the additional information about the risk reduction methods and need to take regular supervised treatment.

  Acknowledgment Top

We sincerely thank Mr. Z. H. Zaidi, Lecturer of Biostatics, Department of Community Medicine, Era's Lucknow Medical College, Lucknow for his constant support for statistical analysis of this research work.

  References Top

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  [Table 1], [Table 2], [Table 3], [Table 4]

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