Home About us Editorial board Search Ahead of print Current issue Archives Submit article Instructions Subscribe Contacts Login 
Visit old site
Home Print this page Email this page Small font size Default font size Increase font size
Users Online: 79
Year : 2014  |  Volume : 6  |  Issue : 1  |  Page : 41-47

Evaluation of regression in autism spectrum disorder based on parental reports

1 Department of Research, Institute of Chronic Illness, Inc., Silver Spring, Maryland; Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA
2 Department of Research, Institute of Chronic Illness, Inc., Silver Spring, Maryland, USA

Correspondence Address:
Janet K Kern
Institute of Chronic Illnesses, Inc., 14 Redgate Court, Silver Spring, Maryland 20905
Login to access the Email id

Source of Support: This research was funded by grants from the non-profi t Autism Research Institute, the non-profi t CoMeD, Inc., and the non-profi t Institute of Chronic Illnesses, Inc. through a grant from the Brenen Hornstein Autism Research and Education Foundation,., Conflict of Interest: The authors have been involved in vaccine/ biologic litigation.

DOI: 10.4103/1947-2714.125867

Rights and Permissions

Background: Research indicates that some children with autism spectrum disorder (ASD) experience a developmental regression. Aims: The study examined the percentage of children with autism, pervasive developmental disorder (PDD), ASD, and Asperger syndrome (AS) who were considered to be delayed (D), regressed (R), or delayed and later regressed (DR) and examined any relationship with autism severity, time of onset, factors associated with onset, gastrointestinal (GI) symptoms, race, age, and gender. Materials and Methods: The study reviewed developmental and medical information based on parental reports of 135 children with a diagnosis of autism, PDD, ASD, or AS. Results: The number of children in the D group was 53 (39.2%) with 19 (14.1%) in the DR group and 63 (46.7%) in the R group. Thus, 82 children (60.7%) were reported to have R. In regard to onset of symptoms, there was a significant difference between the D and R groups as well as between the DR and R groups. The analyses showed that there was no significant relationship between age, gender, race, severity, or GI symptoms and membership in any group; D, DR, or R. The majority of parents reported that the regression was preceded by or was associated with vaccinations (57.3%) or another medically related event (11.0%). Conclusions: The findings are consistent with previous research and reinforce our understanding of regression in those children with an ASD diagnosis.

Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)

 Article Access Statistics
    PDF Downloaded495    
    Comments [Add]    
    Cited by others 13    

Recommend this journal