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ORIGINAL ARTICLE
Year : 2014  |  Volume : 6  |  Issue : 8  |  Page : 396-402

Correction of low vitamin D improves fatigue: Effect of correction of low vitamin D in fatigue study (EViDiF study)


1 Department of Medicine, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA
2 Cooper Research Institute, Cooper University Hospital, Cooper Medical School of Rowan University, Camden, New Jersey, USA

Correspondence Address:
Satyajeet Roy
Department of Medicine, Cooper University Hospital, 1103 North Kings Highway, Suite 203, Cherry Hill, NJ 08034
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/1947-2714.139291

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Background: Fatigue is a common presenting complaint of patients in the primary care offices. Low levels of vitamin D have been associated with fatigue in cancer patients. Normalization of vitamin D level improves their fatigue. Whether low vitamin D plays a role in fatigue in medically stable patients is not known. Aims: This prospective non-randomized therapeutic study observed the prevalence of low vitamin D in fatigue and the effect of normalization of vitamin D on fatigue. Material and Methods: One hundred and seventy four adult patients, who presented in our primary care office with fatigue and stable chronic medical conditions,completed fatigue assessment questionnaires. Patients with low vitamin D levels received ergocalciferol therapy for 5 weeks. Scores of pre- and post-treatment fatigue assessment questionnaires were compared. Results: Prevalence of low vitamin D was 77.2% in patients who presented with fatigue. After normalization of vitamin D levels fatigue symptom scores improved significantly (P < 0.001) in all five subscale categories of fatigue assessment questionnaires. Conclusion: The prevalence of low vitamin D is high in patients who present with fatigue and stable chronic medical conditions, if any. Normalization of vitamin D levels with ergocalciferol therapy significantly improves the severity of their fatigue symptoms.


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