North American Journal of Medical Sciences

CASE REPORT
Year
: 2011  |  Volume : 3  |  Issue : 4  |  Page : 206--208

Acute pancreatitis and fibromyalgia: Cytokine link


Sadat Muzammil1, Helen Catherine Cooper2 
1 Mid Cheshire Hospitals NHS Foundation Trust, Crewe, Cheshire CW1 4QJ, England, United Kingdom
2 St Helens and Knowsley Teaching Hospitals NHS Trust, Prescot, Merseyside. L35 5DR, England, United Kingdom

Correspondence Address:
Sadat Muzammil
General Practice Specialty Registrar, Mid Cheshire Hospitals NHS Foundation Trust, Crewe, Cheshire. CW1 4QJ
United Kingdom

Context: Fibromyalgia is a widespread musculoskeletal pain disorder found in 2% of the general population and with a preponderance of 85% in females, and has both genetic and environmental contribution. Acute pancreatitis is a severe condition and in most cases gallstones disease represents approximately half of the cases of acute pancreatitis, and 20-25% are related to alcohol abuse. Small numbers of cases are caused by a variety of other reasons but a few cases have no obvious cause, referred to as «SQ»idiopathic«SQ». Here we present a case where fibromyalgia might be linked to acute pancreatitis. We believe this has not been reported in this context in literature. Case Report: Fibromyalgia is a widespread musculoskeletal pain disorder found in 2% of the general population and with a preponderance of 85% in females, and has both genetic and environmental contribution. Patient had a cholecystectomy eight years previously. Patient feels tired almost all the time due to her fibromyalgia and requires family support for daily routine. Patient«SQ»s blood results showed alanine transaminase 527 IU/L, alkaline phosphatase 604 IU/L, bilirubin 34 μmol/L, amylase 2257 IU/L, C-reactive protein 19 mg/L, Gamma-Glutamyl transpeptidase 851 IU/L, renal function and electrolytes were within normal limits. The patient was admitted to the high dependency unit with a diagnosis of acute pancreatitis. Conclusion: There is a known increase in levels of cytokines in patients with fibromyalgia. Part of the pathophysiology of acute pancreatitis is related to raised cytokines and immune deregulations. We hypothesize that elevated levels of cytokines in fibromyalgia has led to acute pancreatitis in our patient. Further epidemiological research on the incidence of pancreatitis in cytokine mediated conditions such as fibromyalgia is required.


How to cite this article:
Muzammil S, Cooper HC. Acute pancreatitis and fibromyalgia: Cytokine link.North Am J Med Sci 2011;3:206-208


How to cite this URL:
Muzammil S, Cooper HC. Acute pancreatitis and fibromyalgia: Cytokine link. North Am J Med Sci [serial online] 2011 [cited 2021 Apr 15 ];3:206-208
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=4;spage=206;epage=208;aulast=Muzammil;type=0