North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2011  |  Volume : 3  |  Issue : 6  |  Page : 277--280

Triglycerides, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol in rats exposed to premium motor spirit fumes


Ogbevire L Aberare1, Patrick Okuonghae1, Nathaniel Mukoro1, John O Dirisu2, Favour Osazuwa2, Elvis Odigie2, Richard Omoregie3 
1 Department of Chemical Pathology, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria
2 Department of Medical Microbiology, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria
3 School of Medical Laboratory Science, University of Benin Teaching Hospital, PMB 1111, Benin City, Nigeria

Correspondence Address:
Ogbevire L Aberare
Department of Chemical Pathology, University of Benin Teaching Hospital, PMB 1111, Benin City
Nigeria

Background: Deliberate and regular exposure to premium motor spirit fumes is common and could be a risk factor for liver disease in those who are occupationally exposed. A possible association between premium motor spirit fumes and plasma levels of triglyceride, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol using a rodent model could provide new insights in the pathology of diseases where cellular dysfunction is an established risk factor. Aim: The aim of this study was to evaluate the possible effect of premium motor spirit fumes on lipids and lipoproteins in workers occupationally exposed to premium motor spirit fumes using rodent model. Materials and Methods: Twenty-five Wister albino rats (of both sexes) were used for this study between the 4 th of August and 7 th of September, 2010. The rats were divided into five groups of five rats each. Group 1 rats were not exposed to premium motor spirit fumes (control group), group 2 rats were exposed for 1 hour daily, group 3 for 3 hours daily, group 4 for 5 hours daily and group 5 for 7 hours daily. The experiment lasted for a period of 4 weeks. Blood samples obtained from all the groups after 4 weeks of exposure were used for the estimation of plasma levels of triglyceride, total cholesterol, high density lipoprotein- cholesterol and low density lipoprotein- cholesterol. Result: Results showed significant increase in means of plasma total cholesterol and low density lipoprotein levels (P<0.05). The mean triglyceride and total body weight were significantly lower (P<0.05) in the exposed group when compared with the unexposed. The plasma level of high density lipoprotein, the ratio of low density lipoprotein to high density lipoprotein and the ratio of total cholesterol to high density lipoprotein did not differ significantly in exposed subjects when compared with the control group. Conclusion: These results showed that frequent exposure to petrol fumes may be highly deleterious to the liver cells.


How to cite this article:
Aberare OL, Okuonghae P, Mukoro N, Dirisu JO, Osazuwa F, Odigie E, Omoregie R. Triglycerides, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol in rats exposed to premium motor spirit fumes.North Am J Med Sci 2011;3:277-280


How to cite this URL:
Aberare OL, Okuonghae P, Mukoro N, Dirisu JO, Osazuwa F, Odigie E, Omoregie R. Triglycerides, total cholesterol, high density lipoprotein cholesterol and low density lipoprotein cholesterol in rats exposed to premium motor spirit fumes. North Am J Med Sci [serial online] 2011 [cited 2021 Apr 22 ];3:277-280
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2011;volume=3;issue=6;spage=277;epage=280;aulast=Aberare;type=0