North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2014  |  Volume : 6  |  Issue : 4  |  Page : 168--171

Nicotine alters serum antioxidant profile in male albino Rats


Ibukun Peter Oyeyipo, Yinusa Raji, Adeyombo Folashade Bolarinwa 
 Department of Physiology, College of Health Sciences, Osun State University, Osogbo, Osun State; Laboratory for Reproductive and Developmental Programming, Department of Physiology, College of Medicine, University of Ibadan, Ibadan, Oyo State, Nigeria

Correspondence Address:
Ibukun Peter Oyeyipo
Department of Physiology, College of Health Sciences, Osun State University, Osun State
Nigeria

Background: Oxidative stress has repeatedly been implicated as the leading cause of several disease conditions. Aim: This study was designed to investigate the effects of nicotine administration on serum antioxidant levels in male albino rats. Materials and Methods: Forty male rats (150-180 g) were divided into five groups and treated orally for 30 days. Group I (control) received 0.2 ml/kg normal saline and Groups II and III received 0.5 and 1.0 mg/kg body weight (BW) of nicotine, respectively for 30 days. The fourth and fifth groups were administered with 0.5 and 1.0 mg/kg BW of nicotine for 30 days, but were left untreated for another 30 days. Serum was assayed for nitric oxide (NO), lipid peroxidation, and antioxidant enzyme. Results: The levels of superoxide dismutase (SOD) and catalase (CAT) were significantly decreased (P < 0.05) in 0.5 and 1.0 mg/kg nicotine treated groups. Glutathione peroxidase (GPx) and glutathione reductase (GR) were significantly decreased (P < 0.05), while NO and malondialdehyde (MDA) were significantly increased (P < 0.05) in 1.0 mg/kg treated group when compared with the control. Conclusion: The present study shows that nicotine administration is associated with decreased serum antioxidant and increase lipid peroxidation ameliorated by nicotine withdrawal in male rat.


How to cite this article:
Oyeyipo IP, Raji Y, Bolarinwa AF. Nicotine alters serum antioxidant profile in male albino Rats.North Am J Med Sci 2014;6:168-171


How to cite this URL:
Oyeyipo IP, Raji Y, Bolarinwa AF. Nicotine alters serum antioxidant profile in male albino Rats. North Am J Med Sci [serial online] 2014 [cited 2021 Oct 16 ];6:168-171
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2014;volume=6;issue=4;spage=168;epage=171;aulast=Oyeyipo;type=0