North American Journal of Medical Sciences

CASE REPORT
Year
: 2015  |  Volume : 7  |  Issue : 9  |  Page : 415--420

Hemophagocytic lymphohistiocytosis: A series of five clinical cases in adult patients at a single institution with a review of the literature


David Thomas, Nihar Shah, Hiren Patel, Tapan Pandya, Dron Gauchan, Michael Maroules 
 Department of Medicine, St. Joseph's Regional Medical Center, Paterson, New Jersey, USA

Correspondence Address:
Hiren Patel
Department of Medicine, St. Joseph«SQ»s Regional Medical Center, 703 Main St., Paterson, New Jersey-07503
USA

Context: Hemophagocytic Lymphohistiocytosis or the «DQ»Hemophagocytic Syndrome«DQ» is a spectrum of disorders of regulatory immunomodulatory pathways inciting phagocytosis of hematopoietic cells resulting in end-organ damage. The condition appears in both heritable and non-heritable forms from a multitude of possible environmental triggers, most notably infection. The condition often results in a fatal outcome without prompt diagnosis and treatment. Cases in children have been reported much more frequently and classically than in adult patients. Case Report: In this case series we examined five such cases in adult patients that were found at our institution in a window as small at 2 years with more cases having presented since the time of this writing. In these cases, likely triggers were found ranging from infectious, drug-inducing and even underlying malignancy. The condition can be diagnosed by a set of laboratory and physical criteria (Hemophagocytic Lymphohistiocytosis -2004). Treatment ranges from immunosuppressive agents to chemotherapeutic approaches with variable success. Conclusion: Clinicians must maintain a higher index of suspicion in cases presenting with ominous symptomatology to ensure a prompt diagnosis and effective treatment of this potentially deadly condition.


How to cite this article:
Thomas D, Shah N, Patel H, Pandya T, Gauchan D, Maroules M. Hemophagocytic lymphohistiocytosis: A series of five clinical cases in adult patients at a single institution with a review of the literature.North Am J Med Sci 2015;7:415-420


How to cite this URL:
Thomas D, Shah N, Patel H, Pandya T, Gauchan D, Maroules M. Hemophagocytic lymphohistiocytosis: A series of five clinical cases in adult patients at a single institution with a review of the literature. North Am J Med Sci [serial online] 2015 [cited 2020 Nov 30 ];7:415-420
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2015;volume=7;issue=9;spage=415;epage=420;aulast=Thomas;type=0