North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 8  |  Issue : 2  |  Page : 88--92

Addition of selenium improves immunomodulative effects of glucan


Vaclav Vetvicka, Jana Vetvickova 
 Department of Pathology, University of Louisville, Louisville, Kentucky, USA

Correspondence Address:
Vaclav Vetvicka
Department of Pathology, University of Louisville, 511 S. Floyd, Louisville - 40292, Kentucky
USA

Background: Selenium (Se) is an established essential nutrient that plays a role in various biological processes including cancer development. Similarly, stimulation of immune reactions by β-glucans is well-documented. Aims: In the current study, we focused on the stimulation of phagocytosis and interleukin (IL)-2 production and on potentiation of anticancer immunity by a combination of glucan with two types of Se. Materials and Methods: Phagocytosis was evaluated using synthetic microspheres; cancer development was measured either using breast cancer cells or using lung cancer cells. Results: Using two different murine models of cancer, we showed that the Se/glucan combination strongly suppressed the growth of cancer, mostly probably via stimulation of immunity. Conclusions: A combination of glucan with Se offers superior stimulation of immunity and inhibition of cancer growth.


How to cite this article:
Vetvicka V, Vetvickova J. Addition of selenium improves immunomodulative effects of glucan.North Am J Med Sci 2016;8:88-92


How to cite this URL:
Vetvicka V, Vetvickova J. Addition of selenium improves immunomodulative effects of glucan. North Am J Med Sci [serial online] 2016 [cited 2021 Oct 26 ];8:88-92
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2016;volume=8;issue=2;spage=88;epage=92;aulast=Vetvicka;type=0