North American Journal of Medical Sciences

CASE REPORT
Year
: 2016  |  Volume : 8  |  Issue : 4  |  Page : 194--196

Tocilizumab efficacy in a patient with positive anti-CCP chronic Lyme arthritis


Julianna Hirsch1, Itzhak Rosner2, Doron Rimar2, Lisa Kaly2, Michael Rozenbaum2, Nina Boulman2, Gleb Slobodin3 
1 Department of Medicine, Technion Institute of Technology, Bnai Zion Medical Center, Haifa, Israel
2 Department of Medicine, Technion Institute of Technology; Department of Rheumatology, Bnai Zion Medical Center, Haifa, Israel
3 Department of Medicine, Technion Institute of Technology; Department of Internal Medicine A, Bnai Zion Medical Center, Haifa, Israel

Correspondence Address:
Julianna Hirsch
Faculty of Medicine, Technion Institute of Technology, Haifa, Israel. 32 Hasharon #5 Haifa
Israel

Context: Lyme arthritis, a manifestation of tick-borne Lyme disease, can prove to be refractory to classic treatment. Case Report: We present a case of a 48-year-old male, diagnosed with chronic Lyme arthritis, refractory to recurrent and prolonged courses of doxycycline, ceftriaxone, as well as hydroxychloroquine and methotrexate. The patient responded partially to tumor necrosis factor (TNF)-alpha blockade by etanercept and, finally, entered long-term remission after his treatment was switched to tocilizumab. Conclusion: Off label treatment by biologic disease modifying antirheumatic drugs can be considered in selected patients with severe antibiotic-resistant Lyme arthritis.C.


How to cite this article:
Hirsch J, Rosner I, Rimar D, Kaly L, Rozenbaum M, Boulman N, Slobodin G. Tocilizumab efficacy in a patient with positive anti-CCP chronic Lyme arthritis.North Am J Med Sci 2016;8:194-196


How to cite this URL:
Hirsch J, Rosner I, Rimar D, Kaly L, Rozenbaum M, Boulman N, Slobodin G. Tocilizumab efficacy in a patient with positive anti-CCP chronic Lyme arthritis. North Am J Med Sci [serial online] 2016 [cited 2022 May 22 ];8:194-196
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2016;volume=8;issue=4;spage=194;epage=196;aulast=Hirsch;type=0