North American Journal of Medical Sciences

ORIGINAL ARTICLE
Year
: 2016  |  Volume : 8  |  Issue : 6  |  Page : 250--251

Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials


Pragya Shrestha1, Dilli R Poudel2, Ranjan Pathak2, Sushil Ghimire2, Rashmi Dhital3, Madan R Aryal2, Maryam Mahmood2, Paras Karmacharya2 
1 Department of Internal Medicine, Nanjing Medical University, Nanjing, Jiangsu, China
2 Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania, USA
3 Department of Internal Medicine, Universal College of Medical Sciences, Bhairahawa, Nepal

Correspondence Address:
Dr. Paras Karmacharya
Department of Internal Medicine, Reading Health System, West Reading, Pennsylvania - 19611
USA

Background: Statins modify inflammatory cell signaling during the immune response to infection. This has been considered as a pleotropic effect. Effects of statins in inflammatory conditions such as bacteremia have been found to be controversial. Aims: We examined the effect of statins on the mortality of bacteremia patients. Material and Methods: Major databases were searched for the pertinent clinical trials. Results: Six cohort studies comprising 7553 patients were included. Hospital mortality was lower (15.36% vs 22.28%) in patients on statin. Conclusions: There may be a potential role of statins in similar inflammatory and infective conditions.


How to cite this article:
Shrestha P, Poudel DR, Pathak R, Ghimire S, Dhital R, Aryal MR, Mahmood M, Karmacharya P. Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials.North Am J Med Sci 2016;8:250-251


How to cite this URL:
Shrestha P, Poudel DR, Pathak R, Ghimire S, Dhital R, Aryal MR, Mahmood M, Karmacharya P. Effect of statins on the mortality of bacteremic patients: A systematic review and meta-analysis of clinical trials. North Am J Med Sci [serial online] 2016 [cited 2022 Jul 3 ];8:250-251
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2016;volume=8;issue=6;spage=250;epage=251;aulast=Shrestha;type=0