North American Journal of Medical Sciences

CASE REPORT
Year
: 2016  |  Volume : 8  |  Issue : 7  |  Page : 312--315

Selective serotonin-norepinephrine reuptake inhibitors-induced Takotsubo cardiomyopathy


Rahul Vasudev1, Upamanyu Rampal2, Hiten Patel2, Kunal Patel2, Mahesh Bikkina2, Fayez Shamoon2 
1 Department of Internal Medicine, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA
2 Department of Cardiology, New York Medical College, St Joseph's Regional Medical Center, New Jersey, USA

Correspondence Address:
Rahul Vasudev
Department of Internal Medicine, New York Medical College, St Joseph«SQ»s Regional Medical Center, New Jersey - 07503
USA

Context: Takotsubo translates to «DQ»octopus pot«DQ» in Japanese. Takotsubo cardiomyopathy (TTC) is characterized by a transient regional systolic dysfunction of the left ventricle. Catecholamine excess is the one most studied and favored theories explaining the pathophysiology of TTC. Case Report: We present the case of a 52-year-old Hispanic female admitted for venlafaxine-induced TTC with a review literature on all the cases of Serotonin-norepinephrine reuptake inhibitors (SNRI)-associated TTC published so far. Conclusion: SNRI inhibit the reuptake of catecholamines into the presynaptic neuron, resulting in a net gain in the concentration of epinephrine and serotonin in the neuronal synapses and causing iatrogenic catecholamine excess, ultimately leading to TTC.


How to cite this article:
Vasudev R, Rampal U, Patel H, Patel K, Bikkina M, Shamoon F. Selective serotonin-norepinephrine reuptake inhibitors-induced Takotsubo cardiomyopathy.North Am J Med Sci 2016;8:312-315


How to cite this URL:
Vasudev R, Rampal U, Patel H, Patel K, Bikkina M, Shamoon F. Selective serotonin-norepinephrine reuptake inhibitors-induced Takotsubo cardiomyopathy. North Am J Med Sci [serial online] 2016 [cited 2021 Dec 8 ];8:312-315
Available from: https://www.najms.org/article.asp?issn=1947-2714;year=2016;volume=8;issue=7;spage=312;epage=315;aulast=Vasudev;type=0